高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (6): 1037.

• 研究简报 • 上一篇    下一篇

新型含磷抗原的合成

谢桂阳, 陈柳民, 陈家华, 金声   

  1. 北京大学化学与分子工程学院化学生物学系, 生物有机和分子工程教育部重点实验室, 北京 100871
  • 收稿日期:2002-05-28 出版日期:2003-06-24 发布日期:2003-06-24
  • 通讯作者: 陈家华(1958年出生),男,副教授,从事抗体酶及溶血磷脂酸的研究.E-mail:jhchen@chem.pku.edu.cn E-mail:jhchen@chem.pku.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29972001)资助

Synthesis of a Novel Antigen Containing P

XIE Gui-Yang, CHEN Liu-Min, CHEN Jia-Hua, JIN Sheng   

  1. Key Lab of Bioorganic Molecular Engineering of Ministry of Education, Department of Chemistry and Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2002-05-28 Online:2003-06-24 Published:2003-06-24

关键词: 磷酰肽, 抗原, 催化抗体

Abstract: It is of great importance to study the catalytic antibody that catalyzes the hydrolysis of peptide bond. The synthesis of a new kind of antigen(10) containing phosphorus was reported in this paper, which was designed and synthesized according to hippuryl phenylalanine, a substrate of carboxypeptidase A(CPA). To mimic the structure of the substrate, the free C-terminal carboxylic group was remained. However, it was not easy to synthesize the phosphonamide peptide hapten(7) directly, so compound 5 was synthesized firstly, after the catalytic hydrogenolysis it was coupled with p-nitrobenzoyl chloride to get compound(7). The synthesis of antigen and further preparation of antibody will be a good foundation for the activity study of the antibody.

Key words: Phosphonamide peptide, Antigen, Catalytic antibody

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