高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (6): 1034.

• 研究简报 • 上一篇    下一篇

含羟基的2-烷氧基-2-氧代-1,3,2-二氧磷杂环戊烷及其磷酰胆碱系列的合成与表征

王玲, 杨志谋, 陈林, 徐剑, 沈健, 林思聪   

  1. 南京大学表面和界面化学工程技术研究中心, 南京 210093
  • 收稿日期:2002-06-06 出版日期:2003-06-24 发布日期:2003-06-24
  • 通讯作者: 林思聪(1934年出生),男,教授,从事生物医学材料分子工程研究.E-mail:lingchem@sina.com E-mail:lingchem@sina.com
  • 基金资助:

    “九七三”国家重点基础研究发展规划项目(批推号:G1999064705)资助

Synthesis and Characterization of 2-Chloro-2-oxo-1,3,2-dioxaphospholanes Containing Hydroxyl Group and Corresponding Phosphorylcholines

WANG Ling, YANG Zhi-Mou, CHEN Lin, XU Jian-Min, SHEN Jian, LIN Si-Cong   

  1. Research Center of Surface & Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, China
  • Received:2002-06-06 Online:2003-06-24 Published:2003-06-24

PDF (PC)

被引次数

47

关键词: 羟基磷酰胆碱, 不凝血生物材料, 抗凝血生物材料, 两性离子单体, 两性离子不凝血材料

Abstract: In order to construct the zwitterionic structure of phosphorylcholine onto the surface of biomaterials, five novel phospholanes containing hydroxyl group were synthesized from the corresponding diol and 2-chloro-2-oxo-1,3,2-dioxaphospholane in the presence of THF. Then, five novel phosphorylcholines containing hydroxyl group were prepared by the corresponding phospholane and anhydrous trimethylamine in the presence of acetonitrile. Their structures were characterized by FTIR, 1HNMR and elemental analysis.

Key words: Hydroxylated phosphorylcholine, Nonthrombogenic biomaterials, Antithrombogenic biomaterials, Zwitterionic monomer, Zwitterionic nonthrombogenic biomaterials

中图分类号: 

TrendMD: