高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (4): 565.

• 论文 •    下一篇

数学模型法研究细胞间液中Gd(Ⅲ)对Ca(Ⅱ)物种的影响

王进平, 张海元, 牛春吉   

  1. 中国科学院长春应用化学研究所稀土化学与物理重点实验室, 长春 130022
  • 收稿日期:2002-05-15 出版日期:2003-04-24 发布日期:2003-04-24
  • 通讯作者: 牛春吉(1942年出生),男,硕士,研究员,博士生导师,从事稀土生物无机化学研究.E-mail:cjniu@ns.ciac.jl.cn E-mail:cjniu@ns.ciac.jl.cn
  • 基金资助:

    国家自然科学基金(批准号:29971029);中国科学院长春应用化学研究所稀土化学与物理重点实验室基金资助

Studies on Effect of Gd(Ⅲ) on Ca(Ⅱ) Species in Human Interstitial Fluid by Mathematical Model Method

WANG Jin Ping, ZHANG Hai Yuan, NIU Chun Ji   

  1. Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2002-05-15 Online:2003-04-24 Published:2003-04-24

摘要: 用数学模型法研究了细胞间液中Gd(Ⅲ)对Ca(Ⅱ)物种的影响,并利用人工神经网络方法估算配合物稳定常数.结果表明,细胞间液中Ca(Ⅱ)物种分布受Gd(Ⅲ)总浓度变化的影响.当Gd(Ⅲ)总浓度为其在细胞间液中的本底浓度时,Ca(Ⅱ)主要以自由Ca(Ⅱ)离子(71.0%),[Ca(HCO3)](9.5%)和[Ca(Lac)](6.0%)等物种存在.随着Gd(Ⅲ)浓度的提高,Gd(Ⅲ)主要与Ca(Ⅱ)竞争磷酸根及碳酸根,并有竞争生物小分子配体趋势,从而导致Ca(Ⅱ)物种随Gd(Ⅲ)浓度变化重新分布.

关键词: 细胞间液, Gd(Ⅲ), Ca(Ⅱ), 数学模型法, 人工神经网络

Abstract: The effect of Gd(Ⅲ) on Ca(Ⅱ) species in human interstitial fluid was studied by mathematical model method. Meantime artificial neural network was applied to the estimation of lg β value of some complex. The results show that the variety of concentration of Gd(Ⅲ) has effect on Ca(Ⅱ) species. At the background the concentration of Gd(Ⅲ) in human interstitial fluid, Ca 2+ (71.0%), [Ca(HCO3)](9.5 %) and (6.0%) are main species. With the concentration of Gd(Ⅲ) rising, Gd(Ⅲ) firstly competes with Ca(Ⅱ) for PO43- and CO32-, then tends to compete for other biological low molecular weight ligands. This leads to Ca(Ⅱ) redistribution with the variety of concentration of Gd(Ⅲ).

Key words: Human interstitial fluid, Gd(Ⅲ), Ca(Ⅱ), Mathematical model method, Artificial neural network

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