高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (1): 17.

• 论文 • 上一篇    下一篇

纳米尺寸多酸脂质体复合物的合成及抗肿瘤活性研究

王晓红, 王立敏, 刘景福   

  1. 东北师范大学化学学院, 长春 130024
  • 收稿日期:2002-03-06 出版日期:2003-01-24 发布日期:2003-01-24
  • 通讯作者: 王晓红(1966年出生),女,博士,副教授,主要从事多金属氧酸盐的合成及药物化学研究,现在英国剑桥大学从事金属簇合物的合成及催化方面的应用研究.E-mail:litterhongsd@yahoo.com.cn E-mail:litterhongsd@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(批准号:20171011)资助

Studies on the Synthesis and Antitumor Activity of Polyoxometalate Based Liposome Nanocomplex

WANG Xiao-Hong, WANG Li-Min, LIU Jing-Fu   

  1. College of Chemistry, Northeast Normal University, Changchun 130024, China
  • Received:2002-03-06 Online:2003-01-24 Published:2003-01-24

PDF (PC)

被引次数

38

摘要： 合成了杂多化合物α-K8H6[Si2W18Ti6O77](α-Si2W18Ti6)的脂质体纳米粒子.通过红外、固体核磁和极谱对其结构进行了表征,使用透射电镜和粒径分析仪研究了纳米粒子的形态和粒径分布.所合成的纳米粒子中多酸化合物仍保持母体的结构,纳米粒子的粒径在60～150nm之间.用MTT法测定了不同粒径纳米粒子的体外抗肿瘤活性.发现多酸化合物形成脂质体纳米粒子后稳定性和活性都有所提高.

关键词: 脂质体纳米粒子, 多酸化合物, 体外抗肿瘤活性

Abstract: Liposome encapsulated polyoxometalate α-K8H6[Si2W18Ti6O77](α-Si2W18Ti6) was synthesized by using liposomal encapsulating method. The structure of nanomaterial were characterized by IR spectra, solid NMR spectra and polarography, and the forms and range in size of the nanomaterial were estimated by using TEM and Zetasizer. The results show that the polyoxometalate in the complex retains its parent structure, and the sizes of the complexes are from 60 to 150 nm. By using MTT method, the antitumoral activities of the complexes were assayed. The results showed that after being encapsulated by the liposome, the stability and antitumoral activity of polyoxometalate were enhanced.

Key words: Liposome nanaparticle, Heteropoly acid compound, Antitumoral activity in vitro

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