高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (12): 2393.

• 研究简报 • 上一篇    

血液相溶材料的合成研究(Ⅶ)──一类新的抗血小板粘附高分子材料

周静, 沈健, 林思聪   

  1. 南京大学表面和界面化学工程技术研究中心, 南京210093
  • 收稿日期:2001-08-13 出版日期:2002-12-24 发布日期:2002-12-24
  • 通讯作者: 林思聪(1934年出生),男,教授,主要从事高分子分子工程和高分子生物材料分子工程研究.E-mail:zjp iscf@yahoo.com E-mail:zjpiscf@yahoo.com
  • 基金资助:

    “九七三”国家重点基础研究发展规划项目(批准号:G1999064705)资助

Synthesis Studies on Blood Compatible Materials(Ⅶ)──A Novel Kind of Platelet Adhesion Resistant Polymers

ZHOU Jing, SHEN Jian, LIN Si-Cong   

  1. Research Center of Surface and Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, China
  • Received:2001-08-13 Online:2002-12-24 Published:2002-12-24

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被引次数

46

关键词: 硫-铵内盐高分子, 血小板粘附, 不凝血生物材料

Abstract: According to the hypothesis of "Maintaining normal configuration", the polymers with the structure of sulfo-ammonium inner salt would be nonthrombogenic. In this paper, a series of polymers of 3-N,N-dimethyl-3-N-methacryloyloxyethyl ammonium propanesulfonate(DMAPS) and its copolymers with polyethyleneglycol monomethylether methacrylate were prepared by using different concentrations of monomers and crosslinking agent. Their blood compatibilities were evaluated by platelet adhesion method. The results show that PDMAPS is of excellent platelet adhesion resistance.

Key words: Polysulfo-ammonium inner salt, Platelet adhesion, Anti-platelet adhesive biomaterials

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