高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (12): 2237.

• 研究简报 • 上一篇    下一篇

不同模拟体系中草酸钙结晶的比较研究

欧阳健明1, 姚秀琼1, 钟玖平1, 谢瑜珊1, 白钰1, 邝荔1, 唐雯霞2   

  1. 1. 暨南大学生物矿化与结石病防治研究所, 广州510632;
    2. 南京大学配位化学国家重点实验室, 南京210093
  • 收稿日期:2001-11-08 出版日期:2002-12-24 发布日期:2002-12-24
  • 通讯作者: 欧阳健明(1963年出生),男,博士,教授,从事生物矿化和纳米材料研究.E-mail:toyjm@jnu.edu.cn E-mail:toyjm@jnu.edu.cn
  • 基金资助:

    国家自然科学基金重点项目(批准号:20031010);教育部重点科学技术项目(批准号:1998-121);广东省自然科学基金;南京大学配位化学国家重点实验室开放基金资助

Comparative Investigation of Crystallization of Calcium Oxalate in Different Mimetic Systems

OUYANG Jian-Ming1, YAO Xiu-Qiong1, ZHONG Jiu-Ping1, XIE Yu-Shan1, BAI Yu1, KUANG Li1, TANG Wen-Xia2   

  1. 1. Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China;
    2. Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China
  • Received:2001-11-08 Online:2002-12-24 Published:2002-12-24

PDF (PC)

被引次数

30

关键词: 草酸钙, 尿结石, 扫描电子显微镜, 生物矿化

Abstract: The nucleation, growth and aggregation of calcium oxalate(CaC2O4) crystals were comparatively investigated in five different mimetic systems: water, NaCl solution, artificial urine, healthy urine and lithogenic urine by using scanning electron microscopy(SEM). The effects of original concentration of calcium ion and oxalate ion and crystallization time on the morphology, density and the size of CaC2O4 crystals were discussed. In lithogenic urine, calcium oxalate monohydrate(COM) crystals were the dominant phase. However, a mixture of COM and calcium oxalate dihydrate(COD) with a molar ratio of about 3∶2 was obtained in the healthy urine. COD has a less affinity for renal tubule cell surface, so COD is easy to be expelled out from body and there is a less probability of stone-forming in the healthy urine. The fastest nucleation and growth of CaC2O4 crystals were obtained in water and NaCl solution, respectively. The size of CaC2O4 crystals decreases in the following order: NaCl solution>artificial urine>lithogenic urine>healthy urine>water.

Key words: Calcium oxalate, Urinary stones, SEM, Biomineralization

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