高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (10): 1837.

• 研究论文 • 上一篇    下一篇

以阿拉伯半乳聚糖为载体的磁共振成像造影剂的研究

孙国英, 冯江华, 景凤英, 裴奉奎   

  1. 中国科学院长春应用化学研究所, 长春 130022
  • 收稿日期:2001-12-26 出版日期:2002-10-24 发布日期:2002-10-24
  • 通讯作者: 裴奉奎(1940年出生),男,研究员,博士生导师,从事波谱学技术、方法与应用研究.E-mail:peifk@ciac.j.lcn E-mail:peifk@ciac.j.lcn
  • 基金资助:

    波谱与原子分子物理国家重点实验室资助;长春市科技发展计划基金(批准号:T152004,200019)资助

Arabinogalactan as a Carrier for Contrast Agent in Magnetic Resonance Imaging

SUN Guo-Ying, FENG Jiang-Hua, JING Feng-Ying, PEI Feng-Kui   

  1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2001-12-26 Online:2002-10-24 Published:2002-10-24

摘要: 合成了阿拉伯半乳聚糖修饰的DTPA钆配合物,用红外光谱、元素分析、ICP-AES等手段进行了表征,用竞争性方法研究了其在水溶液中的稳定性,测试了其在水中及BSA溶液中的弛豫性能,并进行了体内成像实验.结果表明,其弛豫效率是目前临床所用造影剂Gd-DTPA的1.5~2.0倍,对肝脏和肾脏MRI信号具有良好的增强效果,是比较好的潜在磁共振成像造影剂.

关键词: 阿拉伯半乳聚糖, 磁共振成像, 造影剂, 弛豫效率

Abstract: Arabinogalactan-Gd-DTPA was synthesized by the reaction of diethylenetriaminepenta-acetic acid(DTPA) bisanhydride with polysaccharide in dry DMSO and characterized by FTIR, elemental analysis and ICP-AES. Its stability was investigated by competition with Ca2+, EDTA, DTPA. The t1-relaxivity is 8.06 mmol-1·L·s-1 in D 2O, 8.48 mmol-1·L·s-1 in 0.725 mmol·L-1 BSA, respectively. t1-weighted MR imaging of rat kidney and liver showed a remarkable enhancement post injection of Arabinogalactan-Gd-DTPA. The results indicate that the arabinogalactan-Gd-DTPA is a potential contrast agent for MRI.

Key words: Arabinogalactan, Magnetic resonance imaging, Contrast agent, Relaxivity

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