高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (12): 1993.

• 研究简报 • 上一篇    下一篇

四[对-(羧基甲氧基)苯基]卟啉金属配合物(M=Zn,Cu,Ni)的π-π配合及其二丁基锡(Ⅳ)酯衍生物的抗癌活性

韩高义1,2, 杨频2   

  1. 1. 南京大学配位化学国家重点实验室, 南京 210093;
    2. 山西大学分子科学研究所, 太原 030006
  • 收稿日期:2000-09-25 出版日期:2001-12-24 发布日期:2001-12-24
  • 通讯作者: 杨　频(1933年出生),男,教授,博士生导师,主要从事生物无机和药物化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29871020);山西省自然科学基金(批准号:991012)资助

Aggregation and π-π Coordination of Tetra[4-carboxymethoxyphenyl] Porphyrin Metal Complex(M=Ni, Cu, Zn) and the Vitro Antitumor Activity of Dibutyltin(Ⅳ) Tetra[4-carboxymethoxyphenyl]porphyrinate

HAN GaoYi1,2, YANG Pin2   

  1. 1. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China;
    2. Institute of Molecule Science Research, Shanxi University, Taiyuan 030006, China
  • Received:2000-09-25 Online:2001-12-24 Published:2001-12-24

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关键词: 四[对-(羧基甲氧基)苯基]卟啉配合物, 二丁基锡(Ⅳ), 体外抗癌活性

Abstract: Tetra[4carboxymethoxyphenyl]porphyrin copper(Ⅱ), nickel(Ⅱ), zinc(Ⅱ) complex and their dibutyltin(Ⅳ) ester derivatives have been synthesized and characterized. The equilibrium constants of the aggregation of the metal porphyrin and the equilibrium constant of the π-π coordination with phenothoroline have been measured by using UVVis titration method. The results show that the equilibrium constants decrease in the order of KCuP> KNiP> KZnP. The vitro antitumor activities of the dibutyltin(Ⅳ) metal porphyrinate has some relation with the ability of aggregation and coordination with ligand of the metal porphyrin.

Key words: Tetra[4carboxymethoxyphenyl]porphyrin complex, Dibutyltin(Ⅳ), Vitro antitumor activity

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