高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (8): 1234.

• 研究简报 • 上一篇    下一篇

含苯并异硒唑酮β-环糊精衍生物的合成及其SOD类酶研究

厉斌, 李莉, 刘育, 郑灏, 段志勇   

  1. 南开大学化学系, 天津 300071
  • 收稿日期:1999-10-26 出版日期:2000-08-24 发布日期:2000-08-24
  • 通讯作者: 刘 育(1954年出生),男,博士,教授,博士生导师,主要从事超分子化学研究.
  • 基金资助:

    国家自然科学基金杰出青年基金(批准号:29625203);天津市自然科学基金(批准号:993601311)

Syhthesis and Superoxide Dismutase Activity Studies of β-Cyclodextrin Derivatives Containing1,2- Benzisoselenazol-3(2H)-one

LI Bin, LI Li, LIU Yu, ZHENG Hao, DUAN Zhi-Yong   

  1. Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received:1999-10-26 Online:2000-08-24 Published:2000-08-24

关键词: 苯并异硒唑酮, &beta, -环糊精, 模拟酶, 超氧化物歧化酶

Abstract: Two novelβ-cyclodextrin derivatives containing 1,2 benzisoselenazol-3(2H)-one have been synthesized by a convenient method in 60% and 55% yields, respectively, and characterized by elemental analysis, IRand 1H NMR. The superoxide dismutase (SOD) activity of these modified β cyclodextrins has been determined by the method of autooxidation of pyrogallol at 298.15 Kin buffer solution(pH = 8.20). The results obtained indicate that these cyclodextrin derivatives possesses relatively high SODactivity up to 179~330 U/mg.

Key words: 1,2-Benzisoselenazol-3-(2H)-one, β-Cyclodextrin, Imitating enzyme, Superoxide dismutase enzyme

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