高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (9): 1394.

• 论文 • 上一篇    下一篇

(+)-1S,2R,5S-8-β-萘基薄荷醇的合成

黄国宾, 吴克美, 黄量   

  1. 中国医学科学院中国协和医科大学药物研究所, 北京 100050
  • 收稿日期:1999-02-07 出版日期:1999-09-24 发布日期:1999-09-24
  • 通讯作者: 黄量
  • 作者简介:黄国宾,男,29岁,博士研究生.
  • 基金资助:

    国家自然科学基金(批准号:29790120)资助课题

The Synthesis of (+)-1S, 2R, 5S-8-β-Naphthylmenthol from R-(+)-Pulegone

HUANG Guo-Bin, WU Ke-Mei, HUANG Liang   

  1. Institute of Meteria Medica, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China
  • Received:1999-02-07 Online:1999-09-24 Published:1999-09-24

摘要: 以R-(+)-Pulegone为起始原料经1,4-加成、溴代、水解、氧化等9步反应合成了手性辅助试剂(+)-1S,2R,5S-8-β-萘基薄荷醇及其差向异构体(-)-1R,2R,5S-8-β-萘基新薄荷醇,总收率分别为24.0%和22.6%.

关键词: 1S, 2R, 5S-8-&beta, 萘基薄荷醇, R-(+)-Pulegone, 手性助剂

Abstract: The chiral auxiliary (+)-1S, 2R, 5S-8-β-naphthylmenthol and its epimer (-)-1R,2R, 5S-8-β-naphthylneomenthol were synthesized by 1, 4-addition, bromination, hydrolysis,oxidation and so on from R-(+)-pulegone in 24.0% and 22.6% overall yield.

Key words: (+)-1S, 2R, 5S-8-β-naphthylmenthol, R-(+)-Pulegone, Chiral auxiliary

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