高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (5): 741.

• 研究简报 • 上一篇    下一篇

α-吡唑基-N-苯基-α-氨基膦酸酯的合成及生物活性的初步研究

张克胜, 穆林静, 龙韫先   

  1. 南开大学元素有机化学研究所, 化学系, 天津 300071
  • 出版日期:1999-05-24 发布日期:1999-05-24
  • 通讯作者: 张克胜,男,30岁,博士,现在中国科学院化学研究所.
  • 作者简介:张克胜,男,30岁,博士,现在中国科学院化学研究所.

Synthesis and Preliminary Bio-activity Studies of α-Pyrazyl-N phenyl-α-aminophosphonates

ZHANG Ke-Sheng, MU Lin-Jing, LONG Yun-Xian   

  1. Institute of Elemento organic Chemistry, Department of Chemistry, Nankai University, Tianjin, 300071
  • Online:1999-05-24 Published:1999-05-24

摘要: α-氨基膦酸及其酯与α-氨基酸结构类似,其具有抑菌[1]、抗肿瘤[2]、杀虫[3]以及抗植物病毒[4~7]的活性.α-氨基膦酸酯上与磷原子相连的2个烷氧基不同、α位碳原子以及氨基上取代基的不同将导致生物活性的巨大差异[8].

关键词: &alpha, -氨基膦酸酯, 吡唑, 生物活性

Abstract: Aseries of α-pyrazyl-N-phenyl-α-aminophosphonates was synthesized by the reaction of phosphites with Schiff bases prepared through condensation of substituted anilines with 5-chloro-1-benzyl-3-methyl-4-pyrazylaldehyde. The reaction can be easily carried out without solvent. The two alkoxyl groups linking to phosphorus atom show unequivalent behavior in 1HNMR. The structures of compounds were confirmed by IR, 1HNMR and elemental analysis. The preliminary bioassay shows that some of them possess good fungicide and anti virus activities on some plants.

Key words: α-Aminophosphonates, Pyrazole, Bio-activity

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