高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (9): 1443.

• 研究简报 • 上一篇    下一篇

2-甲基-2-(2-硝基乙烯基)-1-苯并环酮的对映选择合成

刘大学1, 王锐2   

  1. 兰州大学生物系, 应用有机化学国家重点实验室, 兰州, 730000
  • 收稿日期:1997-08-28 出版日期:1998-09-24 发布日期:1998-09-24
  • 通讯作者: 王锐
  • 作者简介:刘大学,男,39岁,硕士,现为中国人民解放军兰州医学高等专科学校讲师.
  • 基金资助:

    国家自然科学基金(批准号:29502007)资助课题、霍英东教育基金和国家教育委员会博士点专项科研基金(批准号:9473010)资助课题.

Enantioselective Synthesis of 2-Methyl-2-(2-nitroethenyl)-1-benzocyclones

LIU Da-Xue1, WANG Rui2   

  1. Department of Biology, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000
  • Received:1997-08-28 Online:1998-09-24 Published:1998-09-24

PDF (PC)

被引次数

3

关键词: 对映选择合成, 2-甲基-2-(2-硝基乙烯基)-1-苯并环酮, 手性季碳

Abstract: Optical active 2-methyl-2-(2-nitroethenyl)-1-tetralone and 2-methyl-2-(2-nitroethenyl)-1-indanone were synthesized via enantioselective addition elimination reaction between nitroenamine(4) and the enolate of 2-methyl-1-benzocyclone(2). The chromatographic separation yield is 17% 73%. The Econfiguration of the olefinic bond and the enantiomer excess(8%-60%) of products were determined by 400 MHz 1HNMR.

Key words: Enantioselective synthesis, 2-Methyl-2-(2-nitroethenyl)-1-benzocyclone, Chiral quaternary carbon

中图分类号: 

TrendMD: