高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (6): 849.

• 论文 • 上一篇    下一篇

铜(Ⅱ)-α-氨基酸(5-取代邻菲咯啉)-L-苏糖酸三元配合物的稳定性研究

孙祥德1, 殷向晨1, 朱守荣1, 林华宽1, 陈荣悌1, 张兴远2   

  1. 1. 南开大学化学系, 天津, 300071;
    2. 天津巨能化学有限公司, 天津, 300380
  • 收稿日期:1997-05-27 出版日期:1998-06-24 发布日期:1998-06-24
  • 通讯作者: 朱守荣
  • 作者简介:孙祥德,男,34岁,讲师.
  • 基金资助:

    国家自然科学基金

Studies on the Stability of L-Threonic Acid-α-aminoacids(5-Substituted Phenanthrolines)-copper(Ⅱ) Ternary Complexes

SUN Xiang-De1, YIN Xiang-Chen1, ZHU Shou-Rong1, LIN Hua-Kuan1, CHEN Rong-Ti1, ZHANG Xing-Yuan2   

  1. 1. Department of Chemistry, Nankai University, Tianjin, 300071;
    2. Tianjin Juneng Chemical Company Ltd., Tianjin, 300380
  • Received:1997-05-27 Online:1998-06-24 Published:1998-06-24

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摘要： 在298K,I=0.1mol/LKNO3条件下测定了L-苏糖酸-α-氨基酸(5-取代邻菲咯啉)-铜(Ⅱ)三元配合物的生成常数,实验表明,生物配体α-氨基酸及L-苏糖酸具有良好的相容性,其三元配合物的稳定性大于相应二元配合物的稳定性,在较宽的pH值范围内,三元配合物的含量显著大于二元配合物的含量,即L-苏糖酸能作为金属离子的载体,使金属离子易于与氨基酸或蛋白质结合而被动物吸收利用,α-氨基酸及L-苏糖酸问的相容性及其三元配合物的稳定常数随α氨基酸的质子化常数及其二元配合物的稳定常数增加而增加,二者间存在良好的直线自由能关系,而在L-苏糖酸-5-取代邻菲略啉一铜(Ⅱ)三元配合物中,由于d-p反馈π键的存在,三元配合物的稳定常数随取代邻菲咯啉质子化常数的增加而降低,二者之间也存在良好的直线自由能关系.

关键词: L-苏糖酸, &alpha, -氨基酸, 5-取代邻菲咯啉, Cu(Ⅱ)三元配合物, 稳定性

Abstract: The formation constant of α-aminoacids(5 substituted phenanthrolines)-L-threonic-acid-copper(Ⅱ) ternary complexes were determined at 298 K, I =0.1 mol/L KNO3. The two biologically active ligand, α-aminoacid and L-threonic acid accommodate each other when coordinated to copper(Ⅱ) ion. The stability of ternary complex is larger than that of the corresponding binary complex. This result indicates that, as a ligand, L-threonic acid can serve as a carrier transport metal ions effectively in vivo. The percentage of ternary complex is obviously larger than that of binary complex in a wide pHrange. The formation constant of the ternary complexes linearly increase with the increase of protonation constant of α-aminoacid and the stability of its binary complexes. Linear free energy relationship(LFER) does exist in the presence of ternary system. Alcoholic proton in L-threonic acid was dissociated with a pKa larger than that in binary complex. In 5-substituted phenanthroline L-threonic acid-copper(Ⅱ) ternary system, the stability of the ternary complex decreases with the increase of protonation constant of 5-substituted phenanthroline due to d-p π back-bonding.

Key words: L-Threonic acid, α-Aminoacid, 5-Substituted phenanthroline, Copper(Ⅱ) ternary complex, Stability

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