高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (5): 813.

• 论文 • 上一篇    下一篇

聚酯酸酐的合成及其药物释放性能研究

傅杰, 卓仁禧, 范昌烈   

  1. 武汉大学化学系, 国家教育委员会生物医用高分子材料开放实验室, 武汉, 430072
  • 收稿日期:1996-12-23 出版日期:1998-05-24 发布日期:1998-05-24
  • 通讯作者: 卓仁禧
  • 作者简介:傅杰,女,33岁,博士研究生,武汉工业大学副教授.
  • 基金资助:

    国家自然科学基金

Studies on the Syntheses and Properties of Poly(ester anhydride)s for DDS

FU Jie, ZHUO Ren-Xi, FAN Chang-Lie   

  1. Department of Chemistry, Laboratory of Biomedical Polymer Materials of the State Education Commission of China, Wuhan University, Wuhan, 430072
  • Received:1996-12-23 Online:1998-05-24 Published:1998-05-24

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被引次数

27

摘要： 将对羟乙氧基苯甲酸分别与已二酰氯、癸二酰氯和对苯二甲酰氯反应,制备了含酯键的二羧酸.经熔融缩聚,合成了主链含酯键的新型聚酯酸酐.通过1H NMR、IR及元素分析对单体及聚酯酸酐的结构进行了表征.研究了聚酯酸酐的体外降解和药物释放性能,其降解速率和释药速率次序为:聚4,4'-(已二酰氧二乙氧基)双对苯二甲酸＞聚4,4'-(癸二酰氧二乙氧基)双对苯二甲酸＞聚4,4'-(对苯二甲酰氧二乙氧基)双对苯二甲酸.

关键词: 聚酯酸酐, 药物控制释放, 环丙沙星

Abstract: 4,4′-(Adipyldioxyethyoxy)dibenzoic acid(1a), 4,4′-(sebacoyldioxyethyoxy)dibenzoic acid(1b) and 4,4′-(benzoyldioxyethyoxy)dibenzoic acid(1c) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly(ester-anhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by 1H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester-anhydride)s in phosphate buffer solution at 37 ℃ was determined. Drug release profile of Ciprofloxacin was also studied.

Key words: Poly(ester-anhydride), Drug controlled release, Ciprofloxacin

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