高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (2): 292.

• 研究快报 • 上一篇    下一篇

钯催化α-(6-甲氧基-2-萘基)乙醇的不对称羰基化反应

周宏英, 侯经国, 陈静, 李作为, 傅宏祥, 吕士杰   

  1. 中国科学院兰州化学物理研究所, 兰州, 730000
  • 收稿日期:1997-09-27 出版日期:1998-02-24 发布日期:1998-02-24
  • 通讯作者: 傅宏祥
  • 作者简介:周宏英,男,31岁,博士.
  • 基金资助:

    国家自然科学基金资助课题(29473144).

Asymmetric Carbonylation of α-(6-Methoxy-2-naphthyl)ethanol by PdCl2-CuCl2-p-Ts-Chiral Phosphine Catalyst Systems

ZHOU Hong-Ying, HOU Jin-Guo, CHEN Jing, LI Zuo-Wei, FU Hong-Xiang, LU Shi-Jie   

  1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000
  • Received:1997-09-27 Online:1998-02-24 Published:1998-02-24

关键词: &alpha, -(6-甲氧基-2-萘基)乙醇, 不对称羰基化反应, 钯-手性膦催化剂, 萘普生甲酯

Abstract: α-(6-Methoxy-2-naphthyl)ethanol was carbonylated to methyl ester of Naproxen by PdCl2-CuCl2-p-Ts-chiral phosphine catalyst systems under the mild reaction conditions. Poor enantioselectivities and moderate regioselectivities have been obtained by using the ligand DDPPIfor PdCl2-CuCl2-p-Ts catalytic reaction. The effects of P/Pd molar ratio, reaction pressure, and the kinds of solvents have been also investigated with the catalyst system. The asymmetric induction up to 42.5 and good chemical yields have been obtained in the carbonylation of α-(6-methoxy-2 naphthyl)ethanol with carbon monooxide and alcohol.

Key words: α-(6-Methoxy-2-naphthyl)ethanol, Asymmetric carbonylation, Pd-chiral phosphine catalyst, Methyl ester of Naproxen

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