高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (1): 64.

• 论文 • 上一篇    下一篇

磺酰脲的类Mannich反应研究

戴庆, 陈茹玉   

  1. 南开大学元素有机化学研究所及国家重点实验室, 天津, 300071
  • 收稿日期:1996-01-05 出版日期:1997-01-24 发布日期:1997-01-24
  • 通讯作者: 戴庆.男, 28岁, 助研.
  • 作者简介:戴庆.男, 28岁, 助研.
  • 基金资助:

    国家自然科学基金

Studies on the Mannich-type Reaction of p-Toluenesulfonylurea

DAI Qing, CHEN Ru-Yu   

  1. Institute of Elemento-Organic Chemistry and State's Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1996-01-05 Online:1997-01-24 Published:1997-01-24

摘要: 研究了对甲苯磺酰脲与取代苯甲醛及亚磷酸二酯的类Mannich反应,用竞争反应的方法对不同胺组分发生类Mannich反应的活性进行了比较.合成了一系列α-对甲苯磺酰脲基磷酸二酯的化合物.产物的结构得到1HNMR和元素分析的证明.初步生物活性测定结果表明其中某些化合物具有很好的抗烟草花叶病毒活性。

关键词: 对甲苯磺酰脲, 类Mannich反应, &alpha, -氨基膦酸, 生物活性, 抗烟草花叶病毒

Abstract: The Mannich-type reaction invoIving p-toluenesulfonylurea with aromatic aldehy-des and dialkyl phosphite was studied and the reactivities of various kinds of amides were compared by a competing reaction.Anew type of a-amino phosphonic acid derivatives were synthesized and the structures of the products were confirmed by 1HNMRand elemental analyses.The bioassay shows that some of them possess good anti-TMV(Tobacco Mosaic Virus) activity.

Key words: p-Toluenesulfonylurea, Mannich-type reaction, α-Amino phosphonic acid, Biological activity, Anti-TMV

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