高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (9): 1356.

• 论文 • 上一篇    下一篇

利用质谱-质谱法进行稠环芳烃化合物的结构解析

再帕尔·阿不力孜1, 高山光男2, 上田丰甫3   

  1. 1. 中国医学科学院中国协和医科大学药物研究所, 北京, 100050;
    2. 东邦大学药学院;
    3. 明星大学理工学院化学系, 东京, 日本
  • 收稿日期:1995-10-25 出版日期:1996-09-24 发布日期:1996-09-24
  • 通讯作者: 再帕尔·阿不力孜,男,34岁,博士后.
  • 作者简介:再帕尔·阿不力孜,男,34岁,博士后.

Structural Analysis of Condensed Polycyclic Aromatic Compounds by Tandem Mass Spectrometry

Zeper Abliz1, Takavama Mitsuo2, Ueda Toyotoshi3   

  1. 1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050;
    2. Faculty of Pharmaceutical Sciences, Toho University, Chiba 274, Japan;
    3. Department of Chemistry, Meisei University, Tokyo 191, Japan
  • Received:1995-10-25 Online:1996-09-24 Published:1996-09-24

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被引次数

1

摘要： 应用(EI)MS/Ms法研究了吡啶并苯并蒽酮以及苯并苯并蒽酮类异构体的裂解方式及其与结构之间的相关性,探讨了不同异构体中由Mi+产生的[M-H]+、[M-HCN]+、[M-COH]+、[M-CO]i+、[M-(CO+2H)]i+以及[M-(CO+HCN)]i+(i=1,2)等1价及2价离子在MS/MS-CID谱上的强度差异和裂解方式,发现是否含有氮原子以及氮原子和苯环位置的差异,是支配这类化合物在CID谱中裂解行为的主要因素。研究结果表明,2价离子的CID谱能更有效地反映这类杂环芳烃异构体之间的结构差异和裂解特性。

关键词: 稠环芳烃, 吡啶并苯并蒽酮, MS/MS-CID谱, 裂解机理

Abstract: The fragmentation mechanisrn of four isomers of pyridino and benzobenzanthrones was investigated by(EI)tandem mass spectrometry (MS/MS).The relationship between fragmentation pathways and structural characteristics was also discussed.Initial fragmentation pathways have been estimated by the intensities of fragmemt ions[M—H]+,[MHCN]+,[M—COH]+, [M—CO]i+, [M—(CO+2H)]i+and[M—(CO+HCN)]i+ produced from Mi+ (i=1,2).They indicated remarkable differences and very interesting features depending upon the isomer' s component with or without nitrogen, and also the condensation positions of a pyridino or benzo ring to the benzanthrone skeleton.The collisioninduced dissociation(CID)spectra of M2+ ion showed more effectively specific differentiation for their fragmentation behaviors reflecting the structural characteristics of these isomers.

Key words: Polycyclic aromatic hydrocarbon, Pyridinobenzanthrone, MS/MS-CID spectra, Fragmentation mechanism

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