高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (6): 874.

• 论文 • 上一篇    下一篇

乳酸环丙沙星单扫描示波极谱法研究

汪秀龄, 张淑敏, 赫春香   

  1. 辽宁师范大学化学系, 大连 116029
  • 收稿日期:1995-07-31 出版日期:1996-06-24 发布日期:1996-06-24
  • 通讯作者: 汪秀龄,女,58岁,副教授.
  • 作者简介:汪秀龄,女,58岁,副教授.

A Study on Single-sweep Oscillopolarography of Ciprofloxacin Lactate

WANG Xiu-Ling, ZHANG Shu-Min, HE Chun-Xiang   

  1. Deparrment of Chemistry, Liaoning Normal Univervity, Dalian 116029
  • Received:1995-07-31 Online:1996-06-24 Published:1996-06-24

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被引次数

11

摘要： 研究了乳酸环丙沙星的极谱伏安行为。在pH=8.3的0.02ml/LNH4C1-NH3H2O底液中,乳酸环丙沙星能产生1个灵敏的还原峰,峰电位为-1.61Ⅴ,其导数峰高与浓度在3.9×10-8～1.8×10-6mol/L和1.8×10-6～1.1×10-5mol/L范围内呈现良好的线性关系,相关系数r=0.9997,检测下限为2.5×10-8mol/L.用于乳酸环丙沙星注射液的测定,相对标准偏差为0.38%～0.72%,回收率为99.2%～100.5%.大多数金属离子和无机阴离子不干扰测定,此方法还可用于血清、血浆及尿样中痕量乳酸环丙沙星的测定,方法简便、快速、灵敏,用多种电化学手段证明乳酸环丙沙星的还原属于反应物吸附的不可逆过程。

关键词: 乳酸环丙沙星, 单扫描示波极谱法, 极谱行为, 吸附波

Abstract: The polarographic and voltammetric behavior of ciprofloxacin lactate (CFL) and its application were studied.In 0.02 mol/L NH4Cl-NH3. H2O buffer solution (pH= 8.3),a well-defined reduction peak was yielded by CFL.The peak potential(Ep) is about -1.61 V (vs-SCE).Alinear relationship holds between the differential peak height and the concen tration of CFLin the range of 3.9×10-8～1.8×10-5 mol/Land 1.8 ×10-6～1.1×10-5 mol/L, respectively, with r= 0.9997.The limiting detection is 2.5×10-8 mol/L.Most of metallic ions do not interfere the determination.This method is used to determine CFLin raw samples and injections with RSD 0.38%～0.72% and recoveries 99.2%～101.4%, and can also be used to determine the trace CFLin serum, plasma and urine samples.It may provide a simple, rapid and sensitive method for determining clinical medicine and pharmacokinetics.The experimental results show that the reduction of CFLbelongs to an irreversible process of reactant adsorption.The electrode reaction mechanism was preliminarily presented.

Key words: Ciprofloxacin lactate, Single-sweep oscillopolarography, Polarographic behavior, Adsorptive wave

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