高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (4): 571.

• 论文 • 上一篇    下一篇

4-肟醚基喹唑啉类化合物的合成及其抗植物病毒TMV活性

黄润秋, 李慧英, 马军安, 邱德文   

  1. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津 300071
  • 收稿日期:1995-05-16 出版日期:1996-04-24 发布日期:1996-04-24
  • 通讯作者: 黄润秋,男,56岁,教授.
  • 作者简介:黄润秋,男,56岁,教授.
  • 基金资助:

    国家自然科学基金

Synthesis of O-(4-Quinazolinyl)oxime Ethers and Their Antiviral Activity

HUANG Run-Qiu, LI Hui-Ying, MA Jun-An, QIU De-Wen   

  1. Instiuted of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1995-05-16 Online:1996-04-24 Published:1996-04-24

PDF (PC)

被引次数

43

摘要： 4-氯喹唑啉与取代芳香肟在碱存在下进行亲核取代反应,合成了17种新型肟醚基喹唑啉衍生物,并对其结构进行了表征。生物活性测试表明,部分化合物抗植物烟草花叶病毒活性超过抗植物病毒商品药剂2,4-二氧六氢-1,3,5-三嗪。

关键词: 喹唑啉, 肟醚, 抗植物病毒活性

Abstract: The O-(4quinazplinyl)oxime ethers compounds were synthesized by the reactionof 4-chloro quinazoline and substituted aryl oximes under a base.Their structures were confirmed by means of elementary analysis.IR,1H NMRand MS.The preliminary bioassayshows that some compounds have higher antiviral activity against TMV than 1,3,5-triazine-hexahvdro-2,4-dione(DHT);CompoundsⅠ6 and Ⅰ11, at～0.3 mmol/L, results in 60%and 65%inhibition of TMVin nicotiana tabacum leaves respectively, compared to 45% usingDHT,at 0.9mmol/L.

Key words: Quinazoline, Oxime-ether, Antiviral activity

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