高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (3): 414.

• 论文 • 上一篇    下一篇

S-烷基-O-多氯苯基硫代磷(膦)酸衍生物的合成及杀菌活性研究

唐除痴, 金桂玉, 黄光燕, 马缚鹏, 吴桂萍, 贺峥杰, 李树正, 李秉武, 张淑华   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:1995-03-31 出版日期:1996-03-24 发布日期:1996-03-24
  • 通讯作者: 唐除痴,男,56岁,教授.
  • 作者简介:唐除痴,男,56岁,教授.
  • 基金资助:

    国家自然科学基金

Studies on the Synthesis of S-Alkyl-O-polychlorophenyl Thiophosphoric(─nic) Acid Derivatives and Their Fungicidal Activities

TANG Chu-Chi, JIN Gui-Yu, HUANG Guang-Yan, MA Fu-Peng, WU Gui-Ping, HE Zheng-Jie, LI Shu-Zheng, LI Bing-Wu, ZHANG Shu-Hua   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1995-03-31 Online:1996-03-24 Published:1996-03-24

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摘要： O,O-二烷基硫代磷(膦)酸酯与三氯氧磷发生异构化氯化反应生成S-烷基硫代磷(膦)酰氯,后者在缚酸剂存在下与多氯酚反应得到标题化合物。此类化合物也可以用传统方法,从S-烷基硫代磷酰二氯先后与多氯酚及其它亲核试剂反应得到。对所合成的28个新化合物的平碟试验表明,在0.005%浓度下对小麦赤霉等12种植物病菌均表现了明显的抑制活性。

关键词: 硫(醇)代磷酸酯, 硫(醇)代膦酸酯, 异构化反应, 氯化反应

Abstract: The isomerization/chlorination of O,O-dialkyl thiophosphate(-onate)1 with phosphorus oxychloride gives S-alkyl thiophosphorochloride(-nochloride)2,then,the reaction of compounds 2 with polychlorophenol in the presence of triethylamine afford the title compounds 4.Compounds 4 have also been prepared by using the traditional method, thus,the reaction of S-alkyl thiophosphorodichloride 5 with polychorophenol, then with another nucleophile R' Hin the presence of triethylamine can also give the title compounds(4).The results of the tests in the fungicidal activity towards the twelve plant disease fungus show that the twenty-eight compounds 4 prepared possess a satisfactory or excellent fungicidal activity.

Key words: Phosphorothiolate, Phosphonothiolate, Isomerization, Chlorination

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