高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (2): 319.

• 论文 • 上一篇    下一篇

侧链带长链烷酯基和胆甾酯基聚硅氧烷的合成及释药性能研究

胡运华, 卓仁禧   

  1. 武汉大学化学系, 武汉 430072
  • 收稿日期:1995-02-21 出版日期:1996-02-24 发布日期:1996-02-24
  • 通讯作者: 卓仁禧
  • 作者简介:胡运华.男,38岁,博士研究生,副教授.
  • 基金资助:

    国家自然科学基金

The Synthesis and Drug Release Property of Polyorganosiloxanes Containing Pendant Long Alkyl Ester and Cholesteryl Ester Groups

HU Yun-Hua, ZHUO Ren-Xi   

  1. Department of Chemistry, Wuhan University, Wuhan 430072
  • Received:1995-02-21 Online:1996-02-24 Published:1996-02-24

摘要: 报道了侧链带有长链烷酯基和胆甾酯基的聚硅氧烷的合成和相转变性质及由其组成的共混硅橡胶膜对避孕药物左旋十八甲基炔诺酮的释放性能,药物分子透过速率随温度的变化与共混膜中聚硅氧烷的结构和有序状态有关,由晶态转变为液晶态时,透过速率提高。

关键词: 聚硅氧烷, 长链烷酯基, 胆甾酯基, 控制释放, 左旋十八甲基炔诺酮

Abstract: The synthesis and phase transition property of polyorganosiloxanes containing pendant long alkyl ester and cholesteryl ester groups were studied.Drug release property of the blended rubber film of polyorganosiloxanes with PDMSwas also investigated.The results showed that the permeation rate of levonorgesterel(LNG) through the blended rubber film was accelerated as the transform of crystalline phase to liquid crystalline phase of the title polyorganosiloxanes.

Key words: Polyorganosiloxane, Long chain alkyl ester group, Cholesteryl ester group, Controlled release, Levonorgesterel

TrendMD: