高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (2): 190.

• 研究简报 • 上一篇    下一篇

稀土元素与金属硫蛋白作用的研究

黄仲贤, 郑起, 高红英, 顾伟强, 刘芳   

  1. 复旦大学化学系, 上海 200433
  • 收稿日期:1995-04-12 出版日期:1996-02-24 发布日期:1996-02-24
  • 通讯作者: 黄仲贤,男,55岁,教授.
  • 作者简介:黄仲贤,男,55岁,教授.
  • 基金资助:

    国家自然科学基金

The Reactions Between Lanthanons and Metallothionein

HUANG Zhong-Xian, ZHENG Qi, GAO Hong-Ying, GU Wei-Qiang, LIU Fang   

  1. Department of Chemistry, Fudan University, Shanghai 200433
  • Received:1995-04-12 Online:1996-02-24 Published:1996-02-24

关键词: 稀土元素, 金属硫蛋白, 运铁蛋白

Abstract: It was well known that high doses of lanthanons do harm to animal cells in various ways.In this paper the reactions between the lanthanons and the metallothionein(MT)──a heavy metal detoxication protein was studied.The experimental data supported the result that MTcan't bind to lanthanons either in vivo or in votro.In addition,the study proved that lanthanons can not introduce the synthesis of MTin rat liver,even when high doses(0.002%~0.0032%) lanthanum and europium salts were used.The possible reasons were discussed in this paper.

Key words: Lanthanons, Metallothionein, Transferrin

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