高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (11): 1788.

• 论文 • 上一篇    下一篇

乳酸-磷酸酯共聚物为载体的高分子药物的合成及其控释研究

范昌烈, 李兵, 刘振华, 卓仁禧   

  1. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1995-10-30 出版日期:1996-11-24 发布日期:1996-11-24
  • 通讯作者: 范昌烈,男,56岁,副教授.
  • 作者简介:范昌烈,男,56岁,副教授.
  • 基金资助:

    国家自然科学基金

Studies on Synthesis and Controlled-release of Polymer Drug Using Lactic Acid-Phosphate Copolymer as Drug Carriers

FAN Chang-Lie, LI Bing, LIU Zhen-Hua, ZHUO Ren-Xi   

  1. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1995-10-30 Online:1996-11-24 Published:1996-11-24

PDF (PC)

被引次数

19

摘要： 以5-氟尿嘧啶(5-FU)为药物模型,以乳酸-磷酸酯共聚物为高分子药物载体,合成了侧链带药的乳酸-磷酸酯共聚物药物。用1HNMR、IR、UV谱对其结构进行了表征。测定高分子药物中5-FU的含量,研究了高分子药物的体外释药性能及共聚物组成对释药性能的影响。

关键词: 药物控制释放, 高分子药物, 乳酸-磷酸酯共聚物

Abstract: Akind of polymer drug,using 5-flurouril as model drug,lactic acid-phosphate copolymers as polymer drug carriers,was synthesized.The copolymers were characterized by 1H NMR,IRand UVspectroscopy.The contents of 5-fluorouril were determined by UVspectroscopy.The drug release in vitro of the copolymers was studied and the influence of the copolymer composition on the drug release in vitro was investigated.

Key words: Drug controlled-release, Polymer drug, Lactic acid-phosphate copolymer

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