高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (11): 1669.

• 论文 • 上一篇    下一篇

双环β-内酰胺抗生素分子活性构象的理论研究

张士国1, 李红1, 杨频2   

  1. 1. 滨州师范专科学校化学系, 滨州, 256604;
    2. 山西大学分子科学研究所
  • 收稿日期:1994-12-17 修回日期:1995-05-05 出版日期:1995-11-24 发布日期:1995-11-24
  • 通讯作者: 张士国,男,32岁,硕士,讲师.
  • 作者简介:张士国,男,32岁,硕士,讲师.

Theoretical Studies on the Active Conformation for Double-Ring β-Lactam Antibioties

ZHANG Shi-Guo1, LI Hong1, YANG Pin2   

  1. 1. Department of Chemistry, Binzhou Teachers College, Binzhou, 256604;
    2. Institute of Molecular Science, Shanxi University
  • Received:1994-12-17 Revised:1995-05-05 Online:1995-11-24 Published:1995-11-24

PDF (PC)

摘要： 研究了青霉素、△3-头孢菌素和△2-头孢菌素等3种典型双β-内酰胺抗生素的构象与活性的关系,指出桥碳原子和与侧酰胺键相连的碳原子的构型是影响它们活性的重要结构因素。

关键词: &beta, -内酰胺, 分子力学, 构象分析

Abstract: The relationship between conformation and activity of three typical double-ring β-lactam antibioties:penicillin,△3-cephalosprins and △2-cephalosprins was studied in this paper. It is found that the configuration of the bridge carbon atom and the atom attached to the side amide is an important structural factor for their activities.

Key words: β-lactam, Molecular mechanics, Conformation analysis

TrendMD: