高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (10): 1629.

• 论文 • 上一篇    下一篇

水溶性金属卟啉肿瘤靶向磁共振成像造影剂的研究

罗毅1, 梅二文2, 卓仁禧3   

  1. 1. 北京大学化学系, 北京, 100871;
    2. 武汉大学分析测试科学系, 武汉, 430072;
    3. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1994-10-12 修回日期:1995-05-21 出版日期:1995-10-24 发布日期:1995-10-24
  • 通讯作者: 卓仁禧
  • 作者简介:罗毅,男,24岁,博士后.
  • 基金资助:

    国家“863”计划

Studies on Water-Soluble Metalloporphyrins as Tumor Targeting Magnetic Resonance Imaging Contrast Agents

LUO Yi1, MEI Er-Wen2, ZHUO Ren-Xi3   

  1. 1. Department of Chemistry, Peking University, Beijing, 100871;
    2. Department of Analytic Science, Department of Chemistry, Wuhan University, Wuhan, 430072;
    3. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1994-10-12 Revised:1995-05-21 Online:1995-10-24 Published:1995-10-24

PDF (PC)

被引次数

34

摘要： 利用显微荧光-阿达玛变换三维图像分析研究了Cu-TSPP、Mn-TSPP、Cu-TMAP、Mn-TMAP4种水溶性金属卟啉从细胞间质进入肿瘤细胞内的富集过程。对金属卟啉的自旋-晶格弛豫性能(R1)的研究结果表明:Mn(Ⅱ)卟啉配合物的R1值比Gd-DTPA提高了1.5～2倍。

关键词: 水溶性金属卟啉, 肿瘤靶向, 显微荧光-阿达玛变换三维图像分析, 自旋-晶格弛豫性能

Abstract: The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems.Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting.Synthesis of targeting MRI contrast agents for specific tissue and organs is the most attractive field in the recent MRI studies.In this work,four water-soluble metalloporphyrins,Cu(Ⅱ)-TSPP,Mn(Ⅱ)-TSPP.Cu(Ⅱ)-TMAP,Mn(Ⅲ)-TMAP Were synthesized and their structures were confirmed by UV,IR,1HNMR and elemental analysis.Targeting to S180tumor cells of these water-soluble porphyrins was studied in vitro by microscope fluorescence-Hadamard transform three-dimensional image analysis.The spin-lattice relaxivity(R1)of Mn(Ⅱ)-porphyrin chelate is 1.5-2 times larger than that of Gd-DTPA.

Key words: Water-soluble metalloporphyrin, Tumor targeting, Microscope fluorescence-Hadamard transform three-dimensional image analysis, Spin-lattice relaxivity

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