高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (1): 75.

• 论文 • 上一篇    下一篇

β-阻断剂的确证方法研究

徐友宣, 张长久, 申利, 吴筠, 王杉   

  1. 国家体育运动委员会运动医学研究所兴奋剂检测中心, 北京 100029
  • 收稿日期:1994-01-18 修回日期:1991-04-12 出版日期:1995-01-24 发布日期:1995-01-24
  • 通讯作者: 徐友宣,男,31岁,硕士,副研究员.
  • 作者简介:徐友宣,男,31岁.硕士,副研究员.
  • 基金资助:

    国家体育运动委员会科研基金

A Study of the Conformation of Some β-blockers

XU You-Xuan, ZHANG Chang-Jiu, SHEN Li, WU Yun, WAN Shan   

  1. China Doping Control Centre, National Research Institute of Sports Medicince, Beijing, 100029
  • Received:1994-01-18 Revised:1991-04-12 Online:1995-01-24 Published:1995-01-24

PDF (PC)

摘要： 采用固相提取、酶解结合水溶液中的光气衍生化方法,得到具有特征性质谱的衍生物,使β-阻断剂的确证工作准确、简便、快速。用于实际检测,取得满意结果。

关键词: &beta, －阻断剂, 光气, GC/MS, 衍生化

Abstract: An improved procedurehs been established for the confirmation of some β-blockers in doping control analysis. The derivatives of the drugs and their metabolites have very similar mass spectra and retention time in our previous work, and it's very difficult to distinguish them. The derivatization and the extraction are performed simultaneously by using phosgene as the derivatization reagent in the new procedure. The new derivatives in this paper have very chracteristic mass spectra, and are easy to be confirmed.

Key words: β-Blocker, Phosgene, GC/MS, Derivatization

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