高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (6): 932.

• 研究简报 • 上一篇    下一篇

生物可降解聚磷酸酯的合成及其释药性能研究

罗毅, 卓仁禧, 范昌烈   

  1. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1993-05-31 修回日期:1993-11-24 出版日期:1994-06-24 发布日期:1994-06-24
  • 通讯作者: 卓仁禧.
  • 作者简介:罗毅,23岁,博士研究生.
  • 基金资助:

    国家自然科学基金

Synthesis and Drug Release Property of Biodegradable Polyphosphate Esters

LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie   

  1. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1993-05-31 Revised:1993-11-24 Online:1994-06-24 Published:1994-06-24

关键词: 聚磷酸酯, 5-氟尿嘧啶, 药物控制释放

Abstract: Polyphosphate esters were synthesized by the catalytic solution polycondensation of biphenols with dichlorophosphoric acid ethyl ester, dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester, respectively.The polypliosphate esters obtained were characterized by IR, 1H NMRand elementary analysis.The in vitro drug release of 5-fluorouracil was studied in pH7.4 phosphate buffer solution at 37℃.

Key words: Polyphosphate ester, 5-Fluorouracil, Drug-controlled release

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