高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (11): 1643.

• 论文 • 上一篇    下一篇

N-异丙基-O-芳基-O'-半乳吡喃基硫代磷酰胺酯的合成、结构及生物活性

陈茹玉, 陈小茹   

  1. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津, 300071
  • 收稿日期:1993-12-02 修回日期:1994-04-04 出版日期:1994-11-24 发布日期:1994-11-24
  • 通讯作者: 陈茹玉,女.73岁.教授,中国科学院院士.
  • 作者简介:陈茹玉,女,73岁,教授,中国科学院院士.
  • 基金资助:

    国家自然科学基金;南开大学元素有机化学国家重点实验室基金

Synthesis of N-Isopropyl-O-aryl-O'-galatopyranosyl thiophosphoramidates and Their Biological Activity

CHEN Ru-Yu, CHEN Xiao-Ru   

  1. Institute of Elemento-Organic Chemistry, Nankai university, Tianjin, 300071
  • Received:1993-12-02 Revised:1994-04-04 Online:1994-11-24 Published:1994-11-24

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被引次数

1

摘要： 报道了新型N-异丙基-O-芳基O'-半乳吡喃糖基硫代磷酰胺酯的合成,并对有关反应进行了讨论。通过重结晶分离得到了化合物N-异丙基-O-(对-氯苯基)-O'-半乳吡喃糖基硫代磷酰胺酯的纯异构体,单晶X射线衍射分析结果表明,此纯异构体分子中手性磷原子的构型为R.初步测定了这类化合物的除草活性及抗病活性。

关键词: 硫代磷酰胺酯, 半乳吡喃糖基, 除草活性, 抗病活性

Abstract: The synthesis of novel N-isopropyl-O-aryl-O'-galactopyranosyl thiophosphoramidates was reported, and the conditions of the reactions were discussed.Apure isomer of N-isopropyl-O-(p-chlorophenyl)-O'-galactopyranosyl thiophosphoramidate 3d, 3d' , was obtained by recrystallization from diethyl ether-petroleum ether. The result of X-ray diffraction analysis showed that the configuration of the chiral phosphorus atom of 3d' was of R-form.The herbicidal and antidisease activities of the title compounds were tested.

Key words: Thiophosphoramidate, Galactopyranosyl, Herbicidal activity, Antidisease activity

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