高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (3): 349.

• 论文 • 上一篇    下一篇

自旋标记鬼桕类化合物圆二色谱的研究

田瑄, 李景新, 陈耀祖   

  1. 兰州大学应用有机化学国家重点实验室, 兰州, 730000
  • 收稿日期:1991-02-15 出版日期:1992-03-24 发布日期:1992-03-24
  • 通讯作者: 田瑄

Studies on the Circular Dichroism of Spin-Labeled Derivatives of Podophyllotoxin

TIAN Xuan, LI Jing-xin, CHEN Yao-zu   

  1. The National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000
  • Received:1991-02-15 Online:1992-03-24 Published:1992-03-24

摘要: 给已知抗癌药物分子中引入稳定氮氧自由基,合成较母体药物高效低毒的抗癌药物已引起国内外学者的重视[1].我们在具有抗癌活性的鬼桕毒分子中引入稳定氮氧自由基,药理试验表明其活性保持或增加,而毒性却显著地降低[2,3].

关键词: 圆二色谱, 鬼桕, 自施标记, Snatzke球形规则

Abstract: The CD spectra of ten spin-labeled derivatives of podophyllotoxin were studied with CDrule of 1-aryl tetralin compounds and Snatzke's sphere rule.The relationship between the first couple and stereo-configuration and antitumor activity of these compounds were discussed.

Key words: Circular dichroism spectrum, Podophyllotoxin, Spin label, Snatzke's sphere rule

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