高等学校化学学报

高等学校化学学报 ›› 1985, Vol. 6 ›› Issue (4): 341.

• 研究简报 • 上一篇    下一篇

多取代吡咯的合成及其性质(Ⅰ)

李葆, 张书文   

  1. 吉林师范学院化学系
  • 收稿日期:1983-11-27 出版日期:1985-04-24 发布日期:1985-04-24

Synthesis and Properties of Polysubstituted Pyrrole (Ⅰ)

Li Bao, Zhang Shuwen   

  1. Department of Chemistry, Jilin Teacher's College, Jilin
  • Received:1983-11-27 Online:1985-04-24 Published:1985-04-24

PDF (PC)

被引次数

16

摘要： 近年来发现1-位芳基取代吡咯具有明显的生理效应。我们在研究β-二酮与丙烯腈反应之后,首先用乙酰丙酮与对氯-ω-溴代苯乙酮作用,得到1-对氯苯基-3-乙酰基-1,4-戊二酮(1)。然后(1)与各种不同的芳香族伯胺在乙醇和冰醋酸的混合溶剂中(体积比3:4)进行环合反应,生成1,2,3,5-四取代吡咯(2)至(10)。而后(2)至(9)分别与氨基脲反应,得到相应的缩氨脲。这些都是新化合物,其性质见附表。

Abstract: Acetylacetone was treated by p-chloro-ω-bromoacetophenone to give 1-(p-ch-lorophenyl)-3-acetyl-l,4-pentandiketone (1). Nine new 1-aryl-2-methyl-3-acetyl—5-(p-chlorophenyl) pyrroles (2)-(10) have been synthesized by the reaction of (1) with various primary amines. Semicarbazones (11)-(18) were prepared from (2)-(9).Compounds (1)-(18) are reported for the first time.

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