关键词: 微通道反应器, 固定床反应器, 催化加氢, 硝化反应

Abstract: 2-Methyl-5-aminophenol is a crucial high-activity intermediate extensively utilized in the fields of dyes, pharmaceuticals and cosmetics, with a continuously increasing market demand. However, traditional industrial production methods are characterized by high energy consumption, long reaction times and safety concerns. Based on the technical advantages of continuous flow reactors, this study developed a semi-continuous flow synthesis process. By transforming the production processes of three key intermediates into continuous flow processes, the reaction time was significantly reduced from 12 hours to just 4 minutes, and the final product separation yield reached 78.5%. This innovative approach not only significantly improved the reaction efficiency, but also optimized the process conditions, making the product generation more stable, while effectively reducing energy consumption and safety risks. The research results provide an valuable reference for the integrating continuous flow technology with green and efficient industrial production, demonstrating significant industrial application potential.

Key words: Micro-channel reactor, Fixed-bed reactor, Catalytic hydrogenation, Nitration reaction