高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (09): 1886.doi: 10.3969/j.issn.0251-0790.2012.09.002

• 研究快报 • 上一篇    下一篇

金纳米花介导的近红外热疗对人喉癌Hep-2细胞增殖的抑制作用

宋文植1, 姜雅萍1, 纪小会2, 赵丽丽2, 尹万忠3, 杨文胜2   

  1. 1. 吉林大学中日联谊医院, 长春 130033;
    2. 吉林大学化学学院;
    3. 吉林大学第一临床医院, 长春 130012
  • 收稿日期:2012-04-28 出版日期:2012-09-10 发布日期:2012-08-14
  • 通讯作者: 杨文胜,男,博士,教授,博士生导师,主要从事纳米生物医用材料研究.E-mail:wsyang@jlu.edu.cn E-mail:wsyang@jlu.edu.cn
  • 基金资助:

    吉林省科技发展计划项目(批准号: 20110708)和国家自然科学基金(批准号: 50825202)资助.

Inhibition Effect of NIR Photothermal Therapy Mediated by Gold Nanoflowers on Proliferation of Human Laryngocarcinoma Hep-2 Cells

SONG Wen-Zhi1, JIANG Ya-Ping1, JI Xiao-Hui2, ZHAO Li-Li2, YIN Wan-Zhong3, YANG Wen-Sheng2   

  1. 1. China-Japan Union Hospital, Jilin University, Changchun 130033, China;
    2. College of Chemistry;
    3. The First Clinical Hospital, Jilin University, Changchun 130012, China
  • Received:2012-04-28 Online:2012-09-10 Published:2012-08-14

摘要:

采用弱配体柠檬酸钠修饰的金纳米花为介导材料,考察了其对人喉癌Hep-2细胞的NIR热疗作用,结果表明,这种金纳米花材料具有良好的NIR光热转换性能,可有效抑制Hep-2细胞增殖.

关键词: 金纳米花, 柠檬酸钠, 近红外热疗, 人喉癌Hep-2细胞, 热消融

Abstract:

Citrate-capped gold nanoflowers(GNFs) prepared by seeding approach were identified to show efficiently photothermal conversion under the irradiation of 808 nm near-infrared laser. MTT results demonstrate that the photothermal therapy mediated by GNFs inhibits the proliferation of Hep-2 cells effectively, and the inhibition effect increases with the increased concentrations of GNFs and power of the laser. The results of apoptosis and necrosis tested by flow cytometry demonstrate that the photothermal ablation play a predominant role in suppressing the proliferation of the Hep-2 cells. Such citrate-capped GNFs are expected to be a kind of materials potential useful in tumuor NIR photothermal therapy.

Key words: Gold nanoflowers, Sodium citrate, Near-infrared photothermal therapy, Human laryngocarcinoma Hep-2 cell, Thermal ablation

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