The Kinetic Studies of Hydrolysis of 2-, 3- and 4- Bromomethyl Pyridines

Abstract

Abstract: The rates of hydrolysis of 2-, 3- and 4-bromomethyl pyridines to the corresponding hydroxymethyl pyridines at 60℃ and ion strength μ=0.15 over the pHrange from 0.9 to 9.9 in buffer solutions were measured by means of HPLC.Through the mathematical treatment, the first-order and the second-order reaction-rate constants for bromomethyl pyridines and the first-order reaction-rate constants of bromomethyl pyridines conjugated acids were obtained.The mechanisms of the hydrolysis were proposed to be unimolecular nucleophilic substitution(S_N1) and bimolecular nucleophilic substitution (S_N2).

Key words: Kinetics, Hydrolysis,2-,3- and 4-Bromomethyl pyridines, S_N1S_N2

TrendMD:

YE De-Yong, YANG Chu-Yao . The Kinetic Studies of Hydrolysis of 2-, 3- and 4- Bromomethyl Pyridines[J]. Chem. J. Chinese Universities, 1993, 14(8): 1092.

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The Kinetic Studies of Hydrolysis of 2-, 3- and 4- Bromomethyl Pyridines

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