Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion

Chem. J. Chinese Universities

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Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion

WANG Wei¹, JIA Xiao-Hua¹, LIU Yuan¹, WANG Liang¹, YUAN Zhi¹*, TANG Shi-Ming², LIU Min², TANG Hua²

1. Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;
2. Laboratory of Tianjin Life Science Research Center, Tianjin Medical University, Tianjin 300070, China

Received:2007-09-05 Revised:1900-01-01 Online:2008-02-10 Published:2008-02-10
Contact: YUAN Zhi

Abstract

Abstract: Biodegradable α-hydroxyl polyesters, such as poly(lactic acid)(PLA) and poly(lactic-co-glycolic acid)(PLGA) were investigated as scaffolds for tissue engineering. However, polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells. In this study, the functional polylactide with pendant carboxyl(PLMACA) was synthesized, which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA. The structure and composition of PLMACA were confirmed via ¹H NMR spectrum and the compatibilities for blood and cell were stu-died. The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.

Key words: Polylactide, Blood compatibility, Human umbilical vein endothelial cell(HUVEC), Adhesion

CLC Number:

O631.1+1

TrendMD:

WANG Wei¹, JIA Xiao-Hua¹, LIU Yuan¹, WANG Liang¹, YUAN Zhi¹*, TANG Shi-Ming², LIU Min², TANG Hua². Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion

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