Preparation of Temperature- and pH-Sensitive PVME/CMCS Hydrogels via Electron Beam Irradiation Cross-linking and Their Properties

Chem. J. Chinese Universities

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Preparation of Temperature- and pH-Sensitive PVME/CMCS Hydrogels via Electron Beam Irradiation Cross-linking and Their Properties

YU Yang¹, YIN Jing-Bo¹*, LUO Kun¹, XIE Yong-Tao¹, YAN Shi-Feng¹, MA Jia², CHEN Xue-Si²*

1. Department of Polymer Materials, College of Material Science, Shanghai University, Shanghai 201800, China;
2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2007-08-06 Revised:1900-01-01 Online:2008-02-10 Published:2008-02-10
Contact: YIN Jing-Bo,CHEN Xue-Si

Abstract

Abstract: Hydrogels based on poly(vinyl methyl ether) (PVME) and carboxymethylchitosan (CMCS) were prepared with electron beam irradiation(EB) cross-linking at room temperature. The effects of temperature, pH, CMCS content on the swelling properties of PVME/CMCS hydrogels were studied. The release behavior of a drug was tentatively investigated as well. The results show that the gel fraction of PVME/CMCS blend gels increases rapidly and then levels off above the radiation dose of 40 kGy, and it decreases with the increase of CMCS content in PVME/CMCS system. The hydrogels are thermo- and pH-sensitive, and show a fast swelling reversibility. At pH<3.0 and pH>5.0, the hydrogels have a higher swelling ratio; however, the swelling ratio is relatively lower in the pH range of 3.0—5.0 due to the electrostatic force. Increasing CMCS content and decreasing irradiation dose can improve the drug loading. The release of 5-fluorouracil can be governed by regulating the CMCS content and irradiation dose.

Key words: Sensitivity, Hydrogel, Drug release, Poly(vinyl methyl ether), Carboxymethylchitosan

CLC Number:

O631

TrendMD:

YU Yang¹, YIN Jing-Bo¹*, LUO Kun¹, XIE Yong-Tao¹, YAN Shi-Feng¹, MA Jia², CHEN Xue-Si²*. Preparation of Temperature- and pH-Sensitive PVME/CMCS Hydrogels via Electron Beam Irradiation Cross-linking and Their Properties[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Temperature- and pH-Sensitive PVME/CMCS Hydrogels via Electron Beam Irradiation Cross-linking and Their Properties

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