Synthesis and Biological Activity of New Trisubstituted Pyrimidine Phenylsulfonylurea Derivatives

Chem. J. Chinese Universities

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Synthesis and Biological Activity of New Trisubstituted Pyrimidine Phenylsulfonylurea Derivatives

GUO Wan-Cheng, TAN Hai-Zhong, LIU Xing-Hai, LI Yong-Hong, WANG Su-Hua, LI Zheng-Ming*

State Key Laboratory of Elemento-organic Chemistry, National Pesticide Engineering Research Center, Institue of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China

Received:2007-06-08 Revised:1900-01-01 Online:2008-02-10 Published:2008-02-10
Contact: LI Zheng-Ming

Abstract

Abstract: In order to develop new herbicidal active compounds and research the structure-activity relationship, twenty-two new sulfonylurea derivatives with trisubstituting group in the pyrimidine ring were designed and synthesized. Their structures were confirmed by ¹H NMR, MS and elemental analysis. Preliminary herbicidal activity of these new sulfonylurea compounds was determined by pot bioassay experiments at dosage of 1.5 kg/ha. The results show that these trisubstituted pyrimidine phenylsulfonylurea derivatives display weak heribicidal activity and the addition of 5-substituting group of the pyrimidine ring affected the herbicidal activity slightly.

Key words: Sulfonylurea, Pyrimidine, Herbicidal activity

CLC Number:

O626.41

TrendMD:

GUO Wan-Cheng, TAN Hai-Zhong, LIU Xing-Hai, LI Yong-Hong, WANG Su-Hua, LI Zheng-Ming*. Synthesis and Biological Activity of New Trisubstituted Pyrimidine Phenylsulfonylurea Derivatives[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and Biological Activity of New Trisubstituted Pyrimidine Phenylsulfonylurea Derivatives

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