Syntheses and Biological Activityies of 1-(Substituted Isoxazolyl)-1,2,4-triazoles and 1-(Substituted Pyrimidinyl)-1,2,4-triazoles

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (11): 1740.

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Syntheses and Biological Activityies of 1-(Substituted Isoxazolyl)-1,2,4-triazoles and 1-(Substituted Pyrimidinyl)-1,2,4-triazoles

HUANG Zhen-Nian, LI Zheng-Ming

Elemento-Organic Chemistry Institute, Nankai Univcrsity, Tianjin, 300071

Received:1994-11-26 Revised:1995-07-29 Online:1995-11-24 Published:1995-11-24

Abstract

Abstract: α-Oxo-α-(1,2,4-triazol-1-yl)ketene dithioacetals 1 reacted with hydroxylamine hydrochloride in the presence of barium hydrate in refluxing ethanol to give a mixture of isomeric 1-[5-alkylthioisoxazolyl)-1,2,4-triazoles 2 and 1-(3-alkylthioisoxazolyl)-1,2,4-triazoles 2'].Their mass spectral fragmentation was discussed respectively. On treatment with guanidine and thiourea in a refluxing sodium ethoxide, 1 afforded 1-(substitutedpyrimidinyl)-1,2, 4-triazoles 3 and 4. The preliminary biological tests show that isoxazolyltriazoles 2 and 2' have plant-regulatory activities.

Key words: Synthesis, 1-(Substituted isoxazolyl)triazoles, Pyrimidinyl triazoles, Biological activity

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HUANG Zhen-Nian, LI Zheng-Ming. Syntheses and Biological Activityies of 1-(Substituted Isoxazolyl)-1,2,4-triazoles and 1-(Substituted Pyrimidinyl)-1,2,4-triazoles[J]. Chem. J. Chinese Universities, 1995, 16(11): 1740.

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Syntheses and Biological Activityies of 1-(Substituted Isoxazolyl)-1,2,4-triazoles and 1-(Substituted Pyrimidinyl)-1,2,4-triazoles

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