Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (5): 710.

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Quantitative Structure Activity Relationship Study of Fungicidal O-Ethyl-N-isopropylphosphoro(thioureido) thioates

YANG Hua-Zheng, WU Ye, REN Kang-Tai, ZHANG Yu-Fen   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1994-05-04 Revised:1994-10-12 Online:1995-05-24 Published:1995-05-24

Abstract: The fungicidal activity of a series of O-ethyl-N-isopropylphosphoro(thioureido) thioates was studied. It was found that the activity of these compounds was highly dependent upon the substituents attached to the nitrogen atom and this is a kind of broad spectrum fungicide.The quantitative relationship between the structure of the compounds and their fungicidal activity on the rice sheeth blight (Pellicularia sasakii),wheat bead blight (Gib berella saubinetii), apple alternaria fruit rot (Alternalia mali), cotton soreshin (Rhizoolonia solani),and cercospora spot of sugar beet (Cercospora belocola) were analyzed,respectively,using the physicochemical parametres of the substituents and regression analysis.The re sults were used in guiding the synthesis of higher active compound and verified.

Key words: Phosphorothioates, Thiourea, Fungicidal activity, Quantitative structure activity relationship

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