Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (3): 403.

• Articles • Previous Articles     Next Articles

Synthesis of the Thiosemicarbazides of 1-Aryl-1,4-dihydro-3-carboxy-6- methyl-4-pyridazinone and Their Antiviral Activity Against TMV

ZOU Xia-Juan, JIN Gui-Yu, YANG Zhao   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:2000-12-09 Online:2002-03-24 Published:2002-03-24

Abstract: Several new thiosemicarbazides of 1-aryl-1,4-dihydro-3-carboxy-6-methyl-4-pyridazinone were synthesized by reaction of hydrazide of 1-aryl-1,4-dihydro-6-methylpyridazin-3-carboxy-4-one with arylisothiocyanates. The structures of compounds were confirmed by IR, 1H NMR spectral data and elemental analyses. The preliminary biological test shows that some compounds (2d, 2l, 2t) possess a high antiviral activity against TMV.

Key words: Pyridazinone, Synthesis, Antiphytoviral activity

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