Chem. J. Chinese Universities
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LÜ Juan, AN Ying-Li, HUANG Nan, CHEN Xi, LI Jun-Bo, SHI Lin-Qi*
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Abstract: Complex micelles with insoluble PtBA block as core and PEG as well as P4VP as mixed shell were prepared with self-assembling of poly(tert-butyl acrylate)-b-poly(ethylene glycol)(PtBA45-b-PEG114) and poly(tert-butyl acrylate)-b-poly(4-vinylpyridine)(PtBA60-b-P4VP80) in water at pH=2.5. The result of dynamic light scattering(DLS) indicates that the complex micelles show a larger size than that of the individual micelles comprised of PtBA45-b-PEG114 or PtBA60-b-P4VP80 respectively. Increasing the pH value from 2.5 to 12, the P4VP chains will collapse upon the PtBA core because of their deprotonation, and hydrophilic PEG chains will pass through collapsed P4VP layer from the core and stabilize the whole micelle. Thus, channels inside the P4VP layer will form around insoluble PEG chains. Ibuprofen is loaded in these complex micelles at pH=2.5, and then releasing with increasing pH value to 12. The results indicate that channels on the surface of PtBA core can control the release of ibuprofen, and the release velocity is directly proportional to the percentage of channels on the micelles.
Key words: Complex micelle, Channel, Controlled release
CLC Number:
O631
TrendMD:
LÜ Juan, AN Ying-Li, HUANG Nan, CHEN Xi, LI Jun-Bo, SHI Lin-Qi*. Controlled Release for Drug by Complex Micelles of Block Copolymers with Tunable Channels[J]. Chem. J. Chinese Universities, doi: .
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URL: http://www.cjcu.jlu.edu.cn/EN/
http://www.cjcu.jlu.edu.cn/EN/Y2007/V28/I5/982