Controlled Release for Drug by Complex Micelles of Block Copolymers with Tunable Channels

Chem. J. Chinese Universities

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Controlled Release for Drug by Complex Micelles of Block Copolymers with Tunable Channels

LÜ Juan, AN Ying-Li, HUANG Nan, CHEN Xi, LI Jun-Bo, SHI Lin-Qi*

Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

Received:2006-10-23 Revised:1900-01-01 Online:2007-05-10 Published:2007-05-10
Contact: SHI Lin-Qi

Abstract

Abstract: Complex micelles with insoluble PtBA block as core and PEG as well as P4VP as mixed shell were prepared with self-assembling of poly(tert-butyl acrylate)-b-poly(ethylene glycol)(PtBA₄₅-b-PEG₁₁₄) and poly(tert-butyl acrylate)-b-poly(4-vinylpyridine)(PtBA₆₀-b-P4VP₈₀) in water at pH=2.5. The result of dynamic light scattering(DLS) indicates that the complex micelles show a larger size than that of the individual micelles comprised of PtBA₄₅-b-PEG₁₁₄ or PtBA₆₀-b-P4VP₈₀ respectively. Increasing the pH value from 2.5 to 12, the P4VP chains will collapse upon the PtBA core because of their deprotonation, and hydrophilic PEG chains will pass through collapsed P4VP layer from the core and stabilize the whole micelle. Thus, channels inside the P4VP layer will form around insoluble PEG chains. Ibuprofen is loaded in these complex micelles at pH=2.5, and then releasing with increasing pH value to 12. The results indicate that channels on the surface of PtBA core can control the release of ibuprofen, and the release velocity is directly proportional to the percentage of channels on the micelles.

Key words: Complex micelle, Channel, Controlled release

CLC Number:

O631

TrendMD:

LÜ Juan, AN Ying-Li, HUANG Nan, CHEN Xi, LI Jun-Bo, SHI Lin-Qi*. Controlled Release for Drug by Complex Micelles of Block Copolymers with Tunable Channels[J]. Chem. J. Chinese Universities, doi: .

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Controlled Release for Drug by Complex Micelles of Block Copolymers with Tunable Channels

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