Crystal Structure and DNA Cleavage of Pseudorotaxane Composed of Cucurbituril

Chem. J. Chinese Universities

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Crystal Structure and DNA Cleavage of Pseudorotaxane Composed of Cucurbituril

HUO Fang-Jun, YIN Cai-Xia, YANG Pin*

Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China

Received:2006-11-10 Revised:1900-01-01 Online:2007-05-10 Published:2007-05-10
Contact: YANG Pin

Abstract

Abstract: The pseudorotaxane of cucurbituril(CB) with guest molecule 1,6-bis(imidazol-1-yl)hexane dihydrochloride(BIMH-Cl) made pBR322 DNA hydrolyzed efficiently in physiological environment. The cleavage mechanism was proposed that was a cooperation process of the CB molecule and the guest BIMH molecule. In this mechanism, the protonated imidazole might bind DNA via the electrostatic interactions and the CB glycoluril carbonyl oxygen atoms activated a water molecule to attack the phosphorus atom.

Key words: Cucurbituril, Pseudorotaxane, Crystal structure, DNA Cleavage

CLC Number:

O629.7

TrendMD:

HUO Fang-Jun, YIN Cai-Xia, YANG Pin*. Crystal Structure and DNA Cleavage of Pseudorotaxane Composed of Cucurbituril[J]. Chem. J. Chinese Universities, doi: .

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Crystal Structure and DNA Cleavage of Pseudorotaxane Composed of Cucurbituril

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