Chem. J. Chinese Universities
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LIU Xiong-Min*, LI Wei-Guang, LI Piao-Ying, ZHOU Yong-Hong
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Abstract: Synthesis of mcrocyclic lactones has been applied to medical and flavor field. Triglycerides(2) of ω-hydroxycarboxylic acids synthesized from malania oleifera chum oil(1) via ozonization and reduction, and compound 2 were catalytically transformed to macrocyctic lactones(3). This is a new method involving fewer steps and a 61% yield of cyclopentadecanolide was obtained. The reactive properties of macrolactonization of ω-hydroxycarboxylic acids were also studied. The result obtained shows that the priority order of macrolactonization as follows: 11-undecalactone>cyclotridecanolide>cyclopentadecanolide, i.e. the short chain ω-hydroxycarboxylic acids were preferentially cyclized.
Key words: Malania olceifera chum oil, Cyclopentadecanolide, Ozonization, Macrocyclic lactone
CLC Number:
O623.624
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LIU Xiong-Min*, LI Wei-Guang, LI Piao-Ying, ZHOU Yong-Hong. A New Method for Synthesis of Mcrocyclic Lactones via Malania Olceifera Chum Oil[J]. Chem. J. Chinese Universities, doi: .
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http://www.cjcu.jlu.edu.cn/EN/Y2007/V28/I5/897