Synthesis and Biodistribution of (99m)Tc Salicylidene Schiff Base Complex

Abstract

Abstract: One novel complex of (^99m)Tc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis-and trans-(isomers) might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.

Key words: ^99m)Tc, Salicylidene-tyrosine Schiff base complex, Synthesis, Biodistribution

CLC Number:

O614.5

TrendMD:

WANG Ming-Zhao, MENG Zhao-Xing, PENG An, TAN Xin . Synthesis and Biodistribution of (^99m)Tc Salicylidene Schiff Base Complex[J]. Chem. J. Chinese Universities, 2005, 26(5): 816.

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Synthesis and Biodistribution of (^99m)Tc Salicylidene Schiff Base Complex

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