Synthesis of Oligo(ethylenediamino) Modified Permethylated-β-cyclo-dextrins and Their Interactions with Bovine Serum Albumin

Chem. J. Chinese Universities

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Synthesis of Oligo(ethylenediamino) Modified Permethylated-β-cyclo-dextrins and Their Interactions with Bovine Serum Albumin

KANG Shu, CHEN Yong, SHI Jun, MA Yu-Hong, LIU Yu

State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China

Received:2006-04-20 Revised:1900-01-01 Online:2007-03-10 Published:2007-03-10
Contact: LIU Yu

Abstract

Abstract: Two oligo(ethylenediamino) mono-modified permethylated-β-cyclodextrins were prepared, and the complex stability constants for the 8∶1 complexation of some permethylated β-cyclodextrin derivatives with bovine serum albumin were determined by fluorescence and UV-Vis spectroscopy at 25 ℃ in phosphate buffer solution(pH=7.2). The results indicate that the permethylated β-cyclodextrin shows obviously enhanced binding ability as compared with native β-cyclodextrin and 2,6-methylated β-cyclodextrin, and the oligo(ethylenediamino) modified permethylated β-cyclodextrin derivatives show much stronger binding abilities. The enhanced binding ability can be derived from the cooperative effect of hydrophobic, electrostatic and hydrogen bonding interactions.

Key words: Permethylated β-cyclodextrin derivative, Spectral titration, Bovine serum albumin(BSA), Supramolecular chemistry

CLC Number:

O621.3

TrendMD:

KANG Shu, CHEN Yong, SHI Jun, MA Yu-Hong, LIU Yu. Synthesis of Oligo(ethylenediamino) Modified Permethylated-β-cyclo-dextrins and Their Interactions with Bovine Serum Albumin[J]. Chem. J. Chinese Universities, doi: .

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Synthesis of Oligo(ethylenediamino) Modified Permethylated-β-cyclo-dextrins and Their Interactions with Bovine Serum Albumin

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