Research Advances in Vertically-Ordered Mesoporous Silica Films for Electrochemiluminescence Biosensing

doi:10.7503/cjcu20260052

Chem. J. Chinese Universities

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Research Advances in Vertically-Ordered Mesoporous Silica Films for Electrochemiluminescence Biosensing

Li Weixin^1,4, Zeng Yulan², Peng Zhihong^1,4, Chen Zhanfei^3,4, Li Jinqiu^1,4, Chen Zhonghui^1,4, Lin Zhenyu²

1. Central Laboratory, Affiliated Hospital of Putian University 2. Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University 3. Department of Laboratory Medicine, Affiliated Hospital of Putian University 4. Fujian Province University Key Laboratory of Medical Microecology, Pharmaceutical and Medical Technology College, Putian University

Received:2026-01-28 Revised:2026-03-18 Online First:2026-03-25 Published:2026-03-25
Contact: Lin ZhenYu E-mail:zylin@fzu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China (No. 82204102), the Natural Science Foundation of Fujian Province，China(No. 2025J011530), the Project Sponsored by Fujian Provincial Health Technology, China (No. 2025QN01010039) and the Science and Technology Project of Putian, China (Nos. 2025NJYL090, 2025NJYL082)

Abstract

Abstract: Electrochemiluminescence (ECL) biosensing technology demonstrates significant potential in biomedical analysis and clinical diagnosis due to its high sensitivity, low background signal, and excellent controllability. However, traditional materials were commonly confronted problems such as easy leakage of signal molecules, insufficient anti-biocontamination ability, and limited signal amplification capacity for trace target substances during ECL biosening interface assembly. The vertically-ordered mesoporous silica film (VMSF), as a novel nanostructured material, offers an ideal interface for constructing a new generation of high-performance ECL biosensing by virtue of its highly ordered, vertically arranged nano-channel structure, unique size sieving effect, charge selectivity, high specific surface area, and facile modifiability. This review comprehensively outlines the structural characteristics and preparation methods of VMSF, and the functionalization assembly strategies of VMSF interface in ECL biosensing. Then, the latest application progress of VMSF in the detection of small molecules, tumor markers, nucleic acids, drugs, and cells are systematically summarized. Finally, current challenges and future research directions are discussed, aiming to provide insightful perspectives for the rational design of ECL biosensing based on VMSF.

Key words: Vertically-ordered mesoporous silica film, Biosensing; Electrochemiluminescence, Nanochannels

CLC Number:

O657.1

TrendMD:

Li Weixin, Zeng Yulan, Peng Zhihong, Chen Zhanfei, Li Jinqiu, Chen Zhonghui, Lin Zhenyu. Research Advances in Vertically-Ordered Mesoporous Silica Films for Electrochemiluminescence Biosensing[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20260052.

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Research Advances in Vertically-Ordered Mesoporous Silica Films for Electrochemiluminescence Biosensing

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