Resveratrol Nanoparticles Combined with Dissolving Microneedles for Keloid Treatment

doi:10.7503/cjcu20240268

Chem. J. Chinese Universities ›› 2025, Vol. 46 ›› Issue (1): 20240268.doi: 10.7503/cjcu20240268

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Resveratrol Nanoparticles Combined with Dissolving Microneedles for Keloid Treatment

FU Yiying¹^,², XU Wenzhe², RONG Li¹(), LIU Shuwei³()

^1.Department of Plastic Surgery，the First Hospital of Jilin University，Changchun 130021，China
^2.College of Chemistry，Jilin University，Changchun 130012，China
^3.Institute of Translational Medicine，the First Hospital of Jilin University，Changchun 130021，China

Received:2024-06-03 Online:2025-01-10 Published:2024-08-30
Contact: LIU Shuwei E-mail:rong_li@jlu.edu.cn;liushuwei@jlu.edu.cn
Supported by:
the Science and Technology Development Program of Jilin Province, China(20230204091YY)

Abstract

Abstract:

By using resveratrol（RES） and polyethylpyrrolidone（PVP） as raw materials， RES-PVP spherical nanoparticles（RES-PVP NPs） with uniform size were prepared by nano-precipitation method. Then the RES-PVP NPs were loaded into soluble microneedles（MNs） based on hyaluronic acid to prepare the nanodrug-loaded microneedles MN-NPs. The microneedles still maintain high mechanical strength after drug loading， which can meet the needs of penetrating the skin of human scar tissue. The RES-PVP NPs in MN-NPs can induce the apoptosis of human keloid fibroblasts and inhibit their migration. In experiments in vivo， MN-NPs can effectively inhibit the growth of keloid， showing the ability in keloid treatment. The method proposed in this work of transdermal delivery of resveratrol nanodrug using drug-loaded microneedles to treat keloid is feasible， and has good application prospect.

Key words: Resveratrol, Nanodrug, Microneedle, Keloid

CLC Number:

O631

TrendMD:

FU Yiying, XU Wenzhe, RONG Li, LIU Shuwei. Resveratrol Nanoparticles Combined with Dissolving Microneedles for Keloid Treatment[J]. Chem. J. Chinese Universities, 2025, 46(1): 20240268.

Figures/Tables 12

References 22

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Resveratrol Nanoparticles Combined with Dissolving Microneedles for Keloid Treatment

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