Chem. J. Chinese Universities ›› 2022, Vol. 43 ›› Issue (12): 20220577.doi: 10.7503/cjcu20220577

• Review • Previous Articles     Next Articles

Near-infrared-Ⅱ Fluorescence Imaging for Tumor Diagnosis and Therapy

WANG Shiqi1, LUO Bowen1, YU Jicheng1,2,3,4(), GU Zhen1,2,3,4,5()   

  1. 1.Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province,College of Pharmaceutical Science,Zhejiang University,Hangzhou 310058,China
    2.Zhejiang Laboratory of Systems & Precision Medicine,Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 311121,China
    3.Sir Run Run Shaw Hospital of Zhejiang University School of Medicine,Hangzhou 310016,China
    4.Jinhua Institute of Zhejiang University,Jinhua 321299,China
    5.Key Laboratory of Macromolecular Synthesis and Functionalization,Ministry of Education,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China
  • Received:2022-08-31 Online:2022-12-10 Published:2022-10-14
  • Contact: YU Jicheng, GU Zhen E-mail:yujicheng@zju.edu.cn;guzhen@zju.edu.cn
  • Supported by:
    the National Key Research and Development Program of China(2021YFA0909900)

Abstract:

Due to the distinct advantages of deep tissue penetration and high spatial-temporal resolution, near- infrared-Ⅱ(NIR-Ⅱ, 1000—1700 nm) fluorescence imaging technology that developed rapidly in the last decade has attracted extensive attentions for its great potential in tumor diagnosis and therapy. In this review, we first illustrated the mechanism and advantages of fluorescence imaging in the NIR-Ⅱ window. Afterward, the current fluorophores were categorized according to chemical structures, and their properties were introduced respectively. We also highlighted the advances in the development of fluorescence probes and their applications in tumor detection, surgery resection and phototherapy. Finally, we discussed the limitations of current NIR-Ⅱ fluorescence probes and the challenges during clinical translation as well as prospects for future biomedical applications.

Key words: Near-infrared-Ⅱ, Fluorescence imaging, In vivo imaging, Drug delivery, Tumor diagnosis and therapy

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