Recent Advances in Polymeric Nano-sized Carrier Systems †

doi:10.7503/cjcu20190646

Abstract

Abstract:

In recent years, the nanotechnology has attracted a lot of attention in biomedicine owing to the great enhancement of therapeutic efficiency. A variety of polymeric nano-sized carrier systems have been deve-loped for targeted drug delivery and drug controlled release. In order to improve drug accumulation in the focal lesions and reduce the side effects, smart stimuli-responsive nano-sized carriers have emerged. Now, the polymeric nano-sized drug carriers have shown great potential for cancers, metabolic disorders and infectious diseases. This review focuses on the recent advances in polymeric nano-sized carriers and their applications in biomedicine.

Key words: Nanotechnology, Polymer, Nano-sized carrier system, Targeted drug delivery, Drug controlled release

CLC Number:

O633

TrendMD:

ZHAO Yu, CAO Wanqing, LIU Yang. Recent Advances in Polymeric Nano-sized Carrier Systems ^†[J]. Chem. J. Chinese Universities, 2020, 41(5): 909.

Figures/Tables 11

References 91

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Drug	Material	Stimuli-responsive condition	Application	Ref.
Doxorubicin	PEG-b-P(Lys/CA-DOX), PAE-b-P(Lys/CA-DOX)	pH	Cancer	[15]
Doxorubicin	DNA	pH	Cancer	[41]
Doxorubicin	PEG-b-PEYM	pH	Cancer	[38]
Doxorubicin	PLLA-PEG	pH	Cancer	[69]
Doxorubicin	PVA,m-dextran	pH	Cancer	[37]
Doxorubicin	PETMP-AU-PEG	pH	Cancer	[43]
Factor-related apoptosis-inducing ligand and Doxorubicin	m-HA	pH	Cancer	[47]
miRNA	AAm and APm	pH	Cancer	[10]
Doxorubicin, Loperamide	PLGA	pH	Cancer, central analgesic effects	[20]
Methotrexate	Chitosan	pH	Central nervous systems malignancies	[28]
Salvianolic acid B, tanshinone IIA and panax notoginsenoside	PLGA	pH	Cerebral ischemia reperfusion(I/R) injury	[19]
Doxorubicin	Gelatin and polydopamine	pH, enzyme, NIR	Cancer	[30]
Doxorubicin/indocyanine green	PLGA	NIR	Cancer	[68]
Levofloxacin	PVA/SA	UV	Antibiosis	[67]
Curcumin	PEG-pLys	ROS	Alzheimer’s disease	[16]
DNA	Poly(amino thioketal)	ROS	Cancer	[59]
Gemcitabine and anti-PD-L1	PVA-TSPBA	ROS	Cancer	[29]
siRNA	PEG-b-P(Gu/Hb)/Ang-PEG-b-PGu	ROS	Cancer	[60]
MTO	PEG-PolyMTO	ROS	Cancer	[61]
Doxorubicin	poly(ether-urethane)	GSH	Cancer	[53]
Lira	PCGA-PEG-PCGA	Heat	Diabetes	[70]
Doxorubicin	PAMAM	Radiation	Cancer	[26]
Monoclonal Antibodies	2-methacryloyloxyethyl phosphorylcholine	Enzyme	Cancer	[48]
Vancomycin	PEG-b-PP and PEG-b-PC	Enzyme	Antibiosis	[71]
Insulin	Chitosan/alginate and m-dextran	Glucose	Diabetes	[36]
Insulin	PEG-b-(PAA-co-PAAPBA)	Glucose	Diabetes	[72]
Insulin	P(NIPAM-Dex-PBA)	Glucose	Diabetes	[73]
KLVFF	PCL-b-PAE,PCL-b-PEG	—	Alzheimer’s disease	[74]
KLVFF and Beclin-1	PEG	—	Alzheimer’s disease	[75]
Docetaxel	PEG-DMPE, DMPC,DHPC	—	Cancer	[14]
Rivastigmine	Poly(n-butylcyanoacrylate)	—	Alzheimer’s disease	[76]
p53 protein	AAm and N-azidodeca(ethylene glycol)ethylacrylamide	—	Cancer	[52]
Ciprofloxacin	PEG-b-cholesterol	—	Antibiosis	[13]
Ciprofloxacin	PLGA	—	Antibiosis	[77]

Drug	Material	Stimuli-responsive condition	Application	Ref.
Doxorubicin	PEG-b-P(Lys/CA-DOX), PAE-b-P(Lys/CA-DOX)	pH	Cancer	[15]
Doxorubicin	DNA	pH	Cancer	[41]
Doxorubicin	PEG-b-PEYM	pH	Cancer	[38]
Doxorubicin	PLLA-PEG	pH	Cancer	[69]
Doxorubicin	PVA,m-dextran	pH	Cancer	[37]
Doxorubicin	PETMP-AU-PEG	pH	Cancer	[43]
Factor-related apoptosis-inducing ligand and Doxorubicin	m-HA	pH	Cancer	[47]
miRNA	AAm and APm	pH	Cancer	[10]
Doxorubicin, Loperamide	PLGA	pH	Cancer, central analgesic effects	[20]
Methotrexate	Chitosan	pH	Central nervous systems malignancies	[28]
Salvianolic acid B, tanshinone IIA and panax notoginsenoside	PLGA	pH	Cerebral ischemia reperfusion(I/R) injury	[19]
Doxorubicin	Gelatin and polydopamine	pH, enzyme, NIR	Cancer	[30]
Doxorubicin/indocyanine green	PLGA	NIR	Cancer	[68]
Levofloxacin	PVA/SA	UV	Antibiosis	[67]
Curcumin	PEG-pLys	ROS	Alzheimer’s disease	[16]
DNA	Poly(amino thioketal)	ROS	Cancer	[59]
Gemcitabine and anti-PD-L1	PVA-TSPBA	ROS	Cancer	[29]
siRNA	PEG-b-P(Gu/Hb)/Ang-PEG-b-PGu	ROS	Cancer	[60]
MTO	PEG-PolyMTO	ROS	Cancer	[61]
Doxorubicin	poly(ether-urethane)	GSH	Cancer	[53]
Lira	PCGA-PEG-PCGA	Heat	Diabetes	[70]
Doxorubicin	PAMAM	Radiation	Cancer	[26]
Monoclonal Antibodies	2-methacryloyloxyethyl phosphorylcholine	Enzyme	Cancer	[48]
Vancomycin	PEG-b-PP and PEG-b-PC	Enzyme	Antibiosis	[71]
Insulin	Chitosan/alginate and m-dextran	Glucose	Diabetes	[36]
Insulin	PEG-b-(PAA-co-PAAPBA)	Glucose	Diabetes	[72]
Insulin	P(NIPAM-Dex-PBA)	Glucose	Diabetes	[73]
KLVFF	PCL-b-PAE,PCL-b-PEG	—	Alzheimer’s disease	[74]
KLVFF and Beclin-1	PEG	—	Alzheimer’s disease	[75]
Docetaxel	PEG-DMPE, DMPC,DHPC	—	Cancer	[14]
Rivastigmine	Poly(n-butylcyanoacrylate)	—	Alzheimer’s disease	[76]
p53 protein	AAm and N-azidodeca(ethylene glycol)ethylacrylamide	—	Cancer	[52]
Ciprofloxacin	PEG-b-cholesterol	—	Antibiosis	[13]
Ciprofloxacin	PLGA	—	Antibiosis	[77]