Synthesis, Characterization and Anti-tumor Activity of a Novel Supramolecular Compound with α-[Mo8O26]4- and β-[Mo8O26]4-

Abstract

Abstract:

A novel supramolecular compound with the formula [Ni(C₈N₃H₇)₃]₄[Mo₈O₂₆]₂·7H₂O was synthesized by the hydrothermal reaction of (NH₄)₂[Mo₄O₁₃]·2H₂O, NiCl₂·6H₂O and [2-(1H-pyrazol-3-yl)-pyridine].The inorganic-organic hybrid material was characterized by IR spectroscopy, elemental analysis and single-crystal X-ray diffraction. The results of X-ray diffraction indicate that the title complex contains both α- and β-octamolybdates. Leading to the connection between the [Ni(C₈N₃H₇)₃]²⁺ complex cation and [Mo₈O₂₆]^4- through hydrogen bonding interactions, and the connection between the complex cation [Ni(C₈N₃H₇)₃]²⁺ groups through π-π stacking interactions between aromatic rings, two kinds of octamolybdate anions as guests were accommodated in a 3D “honeycomb” host supramolecular network. Therefore, in vitro anti-tumor activity of the compound on human ovarian cancer cells SK-OV-3, human lung cancer cells A549, human cervical cancer cells Hela and human breast cancer cells MCF-7 was studied. The results show that the compound has a certain degree of growth inhibition to three different sources of tumor cells. In particular, the IC₅₀ value to the MCF-7 cells is 6.48 μmol /L, it shows that the compound has the value for further study.

Key words: Hydrothermal synthesis, Molybdenum-oxygen cluster, Anti-tumor activity, in vitro test

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ZHAO Wen-Xiu, LI Yan, DONG Shun-Fu, PENG Jun*. Synthesis, Characterization and Anti-tumor Activity of a Novel Supramolecular Compound with α-[Mo₈O₂₆]^4- and β-[Mo₈O₂₆]^4-[J]. Chem. J. Chinese Universities, 2009, 30(6): 1075.

References

[1]WU Chuan-De(吴传德), ZHAN Xiao-Ping(詹晓平), LU Can-Zhong(卢灿忠), et al.. Chinese J. Struct. Chem.(结构化学)[J], 2002, 21: 525—529
[2]Khan M. I., Yohannes E., Doedens R.. J. Angew. Chem. Int. Ed. Engl.[J], 1999, 38: 1292—1294
[3]Gouzerh P., Proust A.. Chem. Rev.[J], 1998, 98: 77—111
[4]Cui X. B., Yang G. Y.. Chemistry Letters[J], 2002, 31(12): 1238—1239
[5]Contant R., AbbessiM., Thouvenot R., et al.. Inorg. Chem.[J], 2004, 43: 3597—3604
[6]HE Jiang-Hua(何江华), YU Ji-Hong(于吉红), PAN Qin-He(潘勤鹤), et al.. Chem. J. Chinese Universities(高等学校化学学报)[J], 2005, 26(5): 797—800
[7]SHAO Ling(邵玲), ZHANG Qing(张青), ZHOU Xin(周欣), et al.. Chem. J. Chinese Universities(高等学校化学学报)[J], 2007, 28(2): 270—273
[8]YANG Xiao-Gang(杨小刚), LIU Zhi(刘志), YU Qing(于青), et al.. Chem. J. Chinese Universities(高等学校化学学报)[J], 2008, 29(1): 33—36
[9]Sun Z. G., Cui L. Y., Zhu Z. M.. J. Coord. Chem.[J], 2005, 58(15): 1321—1326
[10]DING Hong(丁红), HE Xin(何欣), XU Jia-Ning(徐家宁), et al.. Journal of Jilin University(Science Edition)(吉林大学学报, 理学版)[J], 2006, 44(3): 489—492
[11]YU Ya-Qin(余雅琴), YANG Wen-Bin(杨文斌), WU Chuan-De(吴传德), et al.. Chinese J. Struct. Chem.(结构化学)[J], 2005, 24(2): 214—218
[12]SHEN Yue(沈月), YU Li(于丽), NIU Jing-Yang(牛景杨), et al.. Chinese J. Struct. Chem.(结构化学)[J], 2005, 24(10): 1164— 1168
[13]WANG Zi-Liang(王子梁), WEI Lin-Heng(魏林恒), WANG Jing-Ping(王敬平), et al.. Chemical Research(化学研究)[J], 2005, 16(4): 42—44
[14]CHEN Yi-Ping(陈义平), ZHANG Han-Hui(张汉辉), HUANG Chang-Cang(黄长沧), et al.. Spectroscopy and Spectral Analysis(光谱学与光谱分析)[J], 2006, 26(4): 703—706
[15]LUO Xin-Ze(罗新泽), GUO Hong-You(郭洪猷), YU Jing-Hua(于景华). Journal of Beijing University of Chemical Technology(北京化工大学学报)[J], 2007, 34(3): 267—270
[16]DUAN Xian-Ying(段显英), ZHU Hong-Fei(朱鸿飞), WANG Jing-Ping(王敬平). Chemical Research(化学研究)[J], 2004,15(2): 21—24
[17]WU Chuan-De(吴传德), ZHAN Xiao-Ping(詹晓平), LU Can-Zhong(卢灿忠), et al.. Chinese J. Struct. Chem.(结构化学)[J], 2002, 21(5): 525—529
[18]LIU Jing-Fu(刘景福), WANG Xiao-Hong(王晓红), SUN Zhen-Gang(孙振刚), et al.. Chinese Journal of Applied Chemistry(应用化学)[J], 2001, 18(5): 357—359
[19]Yamase T.. Mol. Eng.[J], 1993, 3: 241—262
[20]ZHANG Xue-Jun(张学军), CHANG Ya-Ping(常雅萍), LIU Jian-Hui(刘建辉), et al.. Immunological Journal(免疫学杂志)[J], 2002, 18(5): 404—405

Synthesis, Characterization and Anti-tumor Activity of a Novel Supramolecular Compound with α-[Mo₈O₂₆]^4- and β-[Mo₈O₂₆]^4-

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