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Synthesis and DNA-cleaving Function of Cyclotriphosphazene Polydentate Ligands

WANG Le1, YE Yong1*, ZHONG Shang-Bin1, ZHANG Di1, ZHAO Yu-Fen1,2*   

    1. Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;
    2. Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
  • Received:2008-06-25 Revised:1900-01-01 Online:2009-03-10 Published:2009-03-10
  • Contact: YE Yong, ZHAO Yu-Fen

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Abstract: A series of multinuclear cyclotriphosphazene ligands were synthesized and used as artificial nuclease enzyme model. All of these new compounds were confirmed by MS, 1H NMR, 31P NMR, 13C NMR and IR. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes were performed. The results strongly suggest that the pUC19 DNA can be cleaved efficiently by these ligands. The effect of DNA cleavage with ligand 5b was also studied under different cleavage time.

Key words: Cyclotriphosphazene, Polydentate ligand, pUC19 DNA, Cleavage

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